Project Grant R41AI129571

Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $427,712 Project Grant to The Regents of the University of Colorado-Denver on March 2, 2026, with completion targeted for February 29, 2028. This award supports research to develop and validate a machine learning-based approach for identifying B cell receptor (BCR) sequences associated with...

Federal Grant Award Summary Syracuse University received a $137,429 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective April 20, 2026 through March 31, 2028. The award funds research and development of tolerogenic dendritic cell (tolDC) membrane-coated nanoparticles designed to provide precision therapy for multiple sclerosis (MS), an autoimmune disease affecting nearly one...

Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Leland Stanford Junior University a $778,827 Project Grant (CFDA 93.855: Allergy and Infectious Diseases Research) on May 8, 2026, with completion anticipated by April 30, 2031. This research initiative will characterize Epstein-Barr virus (EBV)-infected B cells in patients with multiple sclerosis (MS) using an innovative technology platform called ELUCIDATE (EBER-Labeled Unique Cell...

Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded $489,500 to the Benaroya Research Institute at Virginia Mason on February 20, 2026, to support research on inhibiting central nervous system (CNS) resident memory T cells that drive neuroinflammation in multiple sclerosis. The research addresses a critical gap in current disease-modifying therapies by...

Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Washington University a Project Grant totaling $624,300 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research, spanning through January 31, 2031, focuses on characterizing myelin and non-myelin immune responses in multiple sclerosis (MS) through advanced T cell receptor (TCR) sequencing and antigen discovery platforms. The project...

Federal Grant Award Summary Duke University's Office of Research Administration received a $237,476 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2027. This award funds fundamental research investigating the role of Epstein-Barr virus (EBV) in multiple sclerosis (MS) pathogenesis. The research aims to...

This $1,559,700 Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) funds research by the Benaroya Research Institute at Virginia Mason (BRI) to investigate how genetic and epigenetic factors influence T cell function in autoimmune diseases. The key objectives are to: 1) use CRISPR-interference screening to identify regulatory regions that impact T cell proliferation and migration, 2) apply single-cell...

Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a Project Grant totaling $611,634 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research initiative, scheduled for completion on April 30, 2031, investigates age-associated expansion of natural IgM+ FCRL5+ B cell clones as drivers of progressive multiple sclerosis (PMS) and...

Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $397,560 to The Regents of the University of California, San Francisco under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on September 23, 2025, with a completion date of August 31, 2030. This Project Grant funds research into autoimmune mechanisms of metabolic dysfunction in the central nervous system, specifically investigating...

Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of Colorado—Denver a $149,920 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) on January 16, 2026, with performance completion targeted for July 28, 2028. The award funds a cross-species investigation titled "Deciphering Central Nervous System Autoimmunity in Down Syndrome," which will deliver research products examining...