Project Grant R37CA312294
- Federal Grant Award Summary Health Research, Inc. (operating as Health Research at Roswell Park) received a $173,500 Project Grant awarded August 7, 2025, by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to conduct a correlative clinical study investigating the effects of CXCR1/2 inhibition on the immune microenvironment of multiple myeloma patients. The research leverages preliminary findings demonstrating significant accumulation of CXCR2-positive...
- Summary of Federal Project Grant Award The National Cancer Institute (NCI) awarded Health Research, Inc. (operating as Health Research At Roswell Park) a Project Grant of $639,379 under the Cancer Biology Research program (CFDA 93.396) on May 1, 2026, with a completion date of April 30, 2031. The award supports fundamental research to develop and credential neuroendocrine bladder carcinoma (NEBC) models for cross-species comparison and to evaluate innovative treatment approaches. The research...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a Project Grant of $731,503 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective June 1, 2026 through May 31, 2031. This award supports a randomized controlled trial evaluating Brief Behavioral Activation for Older Adult Cancer Survivors (BBA-OACS), a modified psychotherapy intervention specifically designed to address depression and improve health...
- Federal Project Grant Award Summary New York University received a $427,085 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded on August 7, 2025, with completion targeted for July 31, 2027. The grant funds research investigating the relationship between social determinants of health (SDOH)—including food insecurity, dietary quality, and neighborhood-level socioeconomic factors—and cancer-related fatigue (CRF) in...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $630,089 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period May 1, 2026 through April 30, 2031. The award funds research to characterize the molecular mechanisms by which the DNA translocase SMARCAL1 suppresses anti-tumor immune responses and to identify other DNA Damage...
- Federal Project Grant Award Summary Health Research, Inc. (Roswell Park Division) received a $1.15M project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective July 1, 2025, through June 30, 2029. The award supports research focused on leveraging infiltrating myeloid cells to improve therapeutic response to bispecific T cell-engaging (BiTE) secreting T cells in ovarian cancer treatment. This research initiative represents...
- Federal Project Grant Award Summary Health Research, Inc. (operating as Health Research At Roswell Park) received a $929,806 project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective July 1, 2025, through June 30, 2029. The award supports research investigating the therapeutic application of infiltrating myeloid cells to enhance the efficacy of bite-secreting T cells in ovarian cancer treatment. This four-year...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $730,398 Project Grant to the Sloan-Kettering Institute for Cancer Research (Award Date: April 1, 2026; Completion Date: March 31, 2031) under the Cancer Treatment Research program (CFDA 93.395). This research initiative aims to develop novel therapeutic approaches targeting tumor regenerative cells (TRCs) that drive resistance to total neoadjuvant therapy (TNT) in locally advanced rectal cancer (LARC). The project...
- Federal Project Grant Summary The National Cancer Institute awarded $696,498 to the MGH Institute of Health Professions, Inc. on May 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and optimize a multicomponent intervention designed to improve functional recovery and participation in life activities among breast cancer survivors. The project, spanning five years through April 30, 2031, will systematically develop an evidence-based, remotely-delivered...
- Federal Grant Award Summary The University of Rochester received a $639,098 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) beginning August 1, 2025, and concluding July 31, 2030. This award supports research targeting intrinsic and extrinsic barriers to metastatic pancreatic ductal adenocarcinoma (PDAC) treatment. The project develops and evaluates an innovative combination therapy approach designed to overcome treatment resistance...
The National Cancer Institute awarded Health Research, Inc. (operating as Health Research At Roswell Park) a Project Grant totaling $713,312 under the Cancer Cause and Prevention Research program (CFDA 93.393) effective June 1, 2026, through May 31, 2031. This research initiative will elucidate the impacts of body composition and physical activity on anti-tumor immunity and cancer control in advanced-stage high-grade serous ovarian carcinoma (HGSOC). The project addresses a critical gap in understanding how modifiable lifestyle factors—specifically body weight and exercise—influence the tumor immune microenvironment and treatment responsiveness in a highly fatal malignancy where 85% of patients currently demonstrate resistance to immunotherapy. The research will leverage emerging pre-clinical evidence demonstrating that physical activity enhances anti-tumor immunity and cytotoxic immune cell infiltration while mitigating immune-suppressive mechanisms, whereas obesity and physical inactivity promote immune dysregulation. By investigating the relationship between lifestyle factors, immune biomarkers, and HGSOC survival outcomes, this project will generate mechanistic insights and clinical evidence to inform lifestyle-based interventions during active cancer therapy. The work will be performed at Health Research, Inc.'s facilities in Buffalo, New York, and aligns with the Cancer Cause and Prevention Research program's objectives to identify cancer risk reduction strategies and develop mechanisms for cancer prevention and preventive interventions in human populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $713.3k | 5/22/26 |