Project Grant R37CA302677
- Federal Grant Award Summary Mayo Clinic received a $667,710 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective March 20, 2026 through February 28, 2031. This award supports a randomized Phase 2 clinical trial designed to refine personalized treatment strategies for patients with oligometastatic castration-sensitive prostate cancer (OMCSPC) by integrating blood-based biomarkers with stereotactic body radiation therapy...
- Federal Grant Award Summary Mayo Clinic Jacksonville received a $498,582 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded June 1, 2026, with completion scheduled for May 31, 2031. The grant funds fundamental research investigating acetylation as a post-translational modification mechanism that regulates T cell receptor (TCR) signaling to overcome T cell exhaustion in cancer immunotherapy. The research aims to establish SIRT2 (silent...
- Federal Grant Award Summary Mayo Clinic received a $484,803 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 18, 2025, with completion scheduled for July 31, 2030. This research initiative focuses on elucidating glioma risk and improving patient outcomes by integrating germline and somatic genetics analysis. The project addresses critical gaps in understanding the functional relevance of 30 known germline...
- Federal Grant Award Summary The National Cancer Institute awarded The Leland Stanford Junior University a $584,521 Project Grant on August 8, 2025, under the Cancer Treatment Research program (CFDA 93.395) to investigate subclonal determinants of radiation response in soft tissue sarcomas. The research will deliver three primary products: (1) identification and validation of epigenetic changes, including DNA methylation and chromatin accessibility alterations, that confer radioresistance to...
- Federal Grant Award Summary Mayo Clinic received a $367,731 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded May 12, 2026, with a completion date of April 30, 2031. The grant supports research investigating the role of ADAR1P110 (a nuclear isoform of adenosine deaminase acting on RNA) in RNA primer editing during DNA replication and its potential as a therapeutic target for breast cancer, particularly triple-negative...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $901,205 to Boston Children's Hospital under the Cancer Treatment Research program (CFDA 93.395) effective July 3, 2025, with a completion date of June 30, 2032. This research initiative focuses on identifying genome-wide changes in gene expression during early tumorigenesis and metastatic progression to improve immunotherapy efficacy. The project leverages genetically engineered mouse models...
- GRANT AWARD SUMMARY Mayo Clinic received a $412,429 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to conduct research on novel therapeutic combinations for high-grade serous ovarian cancer (HGSOC). The award period extends from August 1, 2025, through July 31, 2027. The research focuses on developing and mechanistically evaluating drug-induced replication stress markers as therapeutic targets, specifically investigating the...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute awarded a $639,295 Project Grant to the Research Institute at Nationwide Children's Hospital on May 8, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393). This award supports a five-year research initiative extending through April 30, 2031, focused on elucidating the molecular mechanisms governing fusion oncoproteins derived from FET (Fused in Ewing sarcoma, Ewsr1, Taf15) family members fused to ETS transcription...
- Federal Project Grant Award Summary Mayo Clinic received a $100,228 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded December 1, 2026, with completion targeted for May 5, 2029. This award supports biomedical research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The grant funds research activities conducted at Mayo Clinic's Rochester, Minnesota facility,...
The National Cancer Institute awarded Mayo Clinic a $659,028 Research Project Grant (R01) under the Cancer Treatment Research program (CFDA 93.395) on May 20, 2026, with a completion date of April 30, 2031. This research initiative focuses on developing novel multi-modality treatment combinations to improve therapeutic outcomes for high-risk Ewing sarcoma patients, specifically those with STAG2 (Stromal Antigen 2) loss who experience significantly worse prognoses. The project addresses critical gaps in understanding radiation therapy-induced immunobiological changes in Ewing sarcoma through investigation of epigenetic reprogramming and immune system activation mechanisms using validated immunocompetent mouse models and human tumor analyses. The primary deliverables include translational research products designed to enhance radiation therapy effectiveness through combination treatments incorporating agents that induce epigenetic reprogramming and tumor inflammation. Preliminary data generated by Mayo Clinic's research team demonstrate that STAG2-deficient Ewing tumors exhibit defective interferon responses and reduced radiation-induced inflammation compared to wildtype tumors, findings validated in both preclinical models and human patient samples. The project aims to leverage identified vulnerabilities in STAG2-deficient tumors to develop evidence-based treatment strategies that optimize local tumor control in aggressive Ewing sarcoma cases, including upfront metastatic and relapsed presentations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $659.0k | 5/22/26 |