The National Cancer Institute (NCI) awarded a $764,565 Project Grant under the CFDA 93.393 Cancer Cause and Prevention Research program to the Sloan-Kettering Institute for Cancer Research. The grant supports a large prospective investigation to validate promising circulating metabolite biomarkers for gastric cancer risk and discover novel biomarkers using metabolomics approaches. The project will harmonize pre-diagnostic plasma samples and epidemiologic data from over 2,800 participants...
This $224,099 Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to develop a targeted colorectal cancer (CRC) screening strategy for adults ages 45-49 to maximize screening uptake and prevent cancer disparities. The key objectives are to:
Characterize the acceptability of CRC screening among adults ages 45-49 through a pilot trial and surveys/interviews to identify factors influencing screening uptake.
Conduct a randomized controlled...
The National Cancer Institute (NCI) awarded a $483,000 Project Grant under the Cancer Biology Research (CFDA 93.396) program to the University of California, Davis (UC Davis). The grant aims to advance the understanding of genomically stable (GS) gastric tumors, which are associated with higher mortality rates among Latino populations.
Through this 2-year project, UC Davis will leverage their expertise in cancer biology, health disparities, and various genomic approaches to characterize the...
This Project Grant award from the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research program) provides $1,623,261 to Case Western Reserve University to conduct a clinical trial aimed at reducing mortality from esophageal adenocarcinoma (EAC).
The key objectives are: 1) Demonstrate the efficacy of a novel non-endoscopic, biomarker-based approach to detect Barrett's esophagus (BE), the precursor to EAC, in patients without gastroesophageal reflux disease (GERD); and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $625,452.00 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research aimed at improving colorectal cancer screening decisions through consideration of patient life expectancy. The research will develop methods to guide clinicians on how to appropriately select older adult patients for colorectal cancer screening, taking into account...
This federal Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program provides $622,913 to the University of California, Los Angeles (UCLA) to evaluate a multilevel intervention to increase colonoscopic follow-up after abnormal stool-based colorectal cancer screening in a community safety-net setting.
The key products and services to be delivered include:
Conducting a pragmatic, cluster randomized trial at Federally...
This $300,000 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program will support a study on the epidemiology of the gut-liver axis and hepatocellular carcinoma (HCC) risk in a diverse cohort of individuals with liver cirrhosis. The University of California, Davis (UC Davis) will lead this 1-year research project, which aims to expand an existing cohort by enrolling approximately 1,000 participants, with a focus on the...
This $501,606 federal Project Grant award, funded by the National Cancer Institute under its Cancer Detection and Diagnosis Research program (CFDA 93.394), aims to develop and characterize a microphysiological system (MPS) platform for modeling peritoneal carcinomatosis (PC), which is a deadly form of metastatic colorectal and gastric cancer. The University of California, Irvine (UC Irvine) will pursue three key objectives: 1) characterize a dual-tissue platform that models PC, 2) correlate...
This Project Grant award of $400,890, provided by the National Cancer Institute (CFDA 93.396 Cancer Biology Research), supports research to profile patient-specific tumor-microbiome interactions and conduct molecular analyses to elucidate microbiome-mediated modulation of immune checkpoint molecules in mismatch repair-proficient, microsatellite-stable colorectal tumors. The research team at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University will utilize...
This federal Project Grant award for $661,831 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to create the Human Cancer Metabolome Atlas (HCMA). The key products and services to be delivered under this 5-year project include:
Analyzing a large-scale collection of over 2,000 patient-derived xenograft (PDX) tumor samples using mass spectrometry-based metabolomics to characterize the cancer metabolome. The PDX models have already been...
This $564,414 Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) aims to establish the feasibility of gastric cancer screening in diverse high-risk populations in the United States. The key products and services to be delivered under this 5-year award include:
Developing and validating a predictive model using structured and unstructured electronic health record data to accurately identify individuals at high risk for gastric cancer. This model will be developed and refined using approximately 5 million patient records from the Cleveland Clinic and Columbia University, and then externally validated on an independent sample of ~3 million patients from the University of California San Diego.
Developing a mathematical model to determine the optimal use of gastric cancer screening by evaluating the potential benefits, harms, and cost-effectiveness. This modeling work will support establishing the foundation for future clinical trials assessing the effectiveness of gastric cancer screening in high-risk populations.
The award was granted to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, a private university and non-profit organization with experience conducting federal biomedical research.