Project Grant R37AI195726
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $835,269 to Harvard Medical School (President and Fellows of Harvard College) on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855). This Project Grant funds basic biomedical research investigating the role of cytokine signaling in high endothelial venule (HEV) formation and maintenance within lymphoid tissues. The research aims to decipher how...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $1,999,706 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support the ImmGen Consortium's immunological research through August 31, 2031. The award funds dissection of gene expression and regulation across all immune system cell lineages through shared data generation pipelines. Specific deliverables include broadening immune transcriptomes...
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College $916,436 through CFDA 93.855 (Allergy and Infectious Diseases Research) on February 5, 2026, to engineer ex vivo thymic tissue capable of supporting functional human T cell development from induced pluripotent stem cells for immunotherapies. The research combines iPSC-derived lymphoid progenitors with engineered biomaterials that recapitulate thymic microarchitecture, addressing current...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College (operating through Harvard Medical School) $160,448 on February 28, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate factors involved in assembly of the mycolata envelope in bacteria of the order Corynebacteriales. The research elucidates the role of the TMAT-AFTD complex in mycomembrane assembly and characterizes new factors required for...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $253,500 on May 21, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how a novel uridyltransferase enzyme named NAGU coordinates peptidoglycan cell wall synthesis with turgor pressure regulation in Staphylococcus aureus. Research will combine genetics, biochemistry, cell biology, and metabolomics to characterize NAGU's cellular roles and...
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College $655,345 on September 19, 2025, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support trainee stipends, tuition, and related costs for eight second- and third-year doctoral students in the Harvard Graduate Program in Bacteriology (GPIB). The GPIB trains PhD students recruited from the Biological and Biomedical Sciences parent program at Harvard Medical...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $463,375 on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to discover antimicrobial metabolites produced by human gut bacteria through high-throughput screening. The research will screen a library of gut bacterial culture and supernatant extracts for growth-inhibitory activity against a panel of bacterial and fungal pathogens and pathobionts...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded President and Fellows of Harvard College $1,136,587 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the spatial spread of T-cell-derived cytokines and their role in immune cell signaling heterogeneity. The research combines in vitro cytokine penetration assays and cyclic immunofluorescence measurements to characterize the spatial extent of cytokines including interleukin-2...
- The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $110,228 on November 23, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop cellular glues—multivalent ligands designed to enhance innate immune responses against fungal pathogens, particularly Candida auris. The recipient will generate multifunctional compounds that simultaneously bind to carbohydrate-binding proteins on C. auris and uptake and...
- The National Institute of Allergy and Infectious Diseases awarded the President and Fellows of Harvard College, operating through Harvard T.H. Chan School of Public Health, $149,163 on September 27, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, Assistance Listing designation F31AI197660). The award funds identification of essential reticulocyte host receptors for Plasmodium vivax invasion using biochemical and functional genomic approaches. The research employs...
The National Institute of Allergy and Infectious Diseases awarded President and Fellows of Harvard College $835,269 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support research on cytokine regulation of lymphocyte trafficking. The project investigates how high endothelial venules (HEV)—specialized microvessels in secondary lymphoid organs—form and function, with emphasis on the role of endothelial CD130 signaling in HEV formation and maintenance. The research explores cytokine signaling via lymphotoxin B, lymphoma inhibitory factor, and oncostatin M in lymph nodes and Peyer's patches using conditional knockout mouse strains. The work aims to elucidate mechanisms that could inform pharmacologic interventions for cancer immunotherapy and inflammatory diseases, given that HEV formation also occurs in sites of chronic inflammation and solid tumors. Harvard Medical School, operating through the Office of Research Administration, performs the work in Boston, Massachusetts. The period of performance runs from February 6, 2026, to January 31, 2031. The award is classified as a Project Grant, the standard NIH mechanism for biomedical research support at universities and nonprofit research institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/6/26 | ||
| Not listed | $835.3k | 2/6/26 |