Project Grant R35NS137336

This two-year, $140,108 project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund research into the co-regulation of striatal dopamine and acetylcholine in associative reward learning. The grantee, The Trustees of Columbia University in the City of New York, will investigate how these two neuromodulators interact to drive associative reward learning processes. Specifically, the researchers will test the hypothesis that striatal...

This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $434,610 to the Florida Institute of Technology Inc. (Florida TECH) for the development of light-triggered molecular tools to manipulate neuronal connections and study brain function. The principal investigator, Dr. Nasri Nesnas, will collaborate with neuroscientists, including Dr. Attila Losonczy from Columbia University, to design and utilize these...

This federal Project Grant award for $1,587,553.00 was provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is focused on developing novel 5-HT3 receptor antagonists for the treatment of neuropathic pain. The key objectives are to: 1) use computational drug design approaches to identify novel 5-HT3 receptor antagonist chemotypes with potential for central nervous system (CNS) penetration and...

This federal Project Grant award of $444,125, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research investigating the role of the serotonergic system in social behavior following early life adversity. The research team at George Washington University will utilize electrophysiology, behavioral assays, and fiber photometry to examine how early life stress alters the excitability of serotonergic neurons and...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will provide $2,565,783 to Oregon Health & Science University (OHSU) from September 1, 2023 to August 31, 2026 to develop novel genetically encoded sensors and actuators for monitoring and manipulating neuromodulatory signaling activities in the brain at the cellular and circuit levels. The project aims to enable large-scale in vivo...

This Project Grant from the National Institutes of Health National Institute on Drug Abuse will fund Neurobehavioral Research Inc. to provide network synchrony neurofeedback training and evaluation for opioid dependent individuals receiving medication assisted treatment. The $807,960 award, issued on September 30, 2021, will support 12 neurofeedback sessions over 8 weeks to train participants' brains to mimic adaptive changes in resting state brain network synchrony seen with long-term...

This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $460,855 to New York University School of Medicine to investigate the cellular and circuit mechanisms by which acetylcholine (ACh) promotes associative learning in the primary somatosensory cortex. The key objectives are to: 1) use fluorescent ACh sensors and chemogenetic techniques to study the magnitude and time course of ACh release during different phases of an...

This Project Grant from the National Science Foundation's Office of International Science and Engineering, under the CFDA program "Office of International Science and Engineering", provides $100,000 to develop a new computational framework for statistical inference of neuromodulation across species and spatial scales from large neural datasets. Vanderbilt University will analyze neural circuitry underlying changes in motivation, mood and alertness using a three-step approach. First,...

Grant Award Summary The National Institute of Mental Health (NIMH) awarded the University of Virginia a $768,909 Project Grant (CFDA 93.242 - Mental Health Research Grants) effective May 1, 2025, through January 31, 2030, to conduct mechanistic research on prefrontal cortex development during critical neonatal periods. The project, titled "Synchronous Network Activity in the Maturing Prefrontal Cortex: Mechanistic Impact of Birth Timing and Serotonin," will investigate how premature...

This federal Project Grant award of $606,029.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the neurocircuitry underlying motivated reward-seeking behavior in response to stress. The key goals of the research are to: 1) Determine if a subpopulation of GABAergic neurons in the medial habenulo-interpeduncular (MHB-IPN) axis...