This Project Grant from the National Science Foundation's Office of International Science and Engineering, under the CFDA program "Office of International Science and Engineering", provides $100,000 to develop a new computational framework for statistical inference of neuromodulation across species and spatial scales from large neural datasets. Vanderbilt University will analyze neural circuitry underlying changes in motivation, mood and alertness using a three-step approach. First, the framework will be validated in neuronal network simulations with known results. Second, it will be applied to zebrafish calcium imaging data to discover neuromodulatory systems benchmarked against anatomy. Third, the framework will be translated to human functional magnetic resonance imaging analysis to infer live human neuromodulation across brain states. This award will accelerate foundational discovery of brain activity and function by delivering an integrative statistical framework for neuromodulation inference from non-invasive imaging across species and scales over the September 15, 2022 to August 31, 2025 award period.
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