Project Grant R35HL184172
- Federal Grant Award Summary Georgia TECH Research Corp received a $502,294 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 3, 2025, with a completion date of April 30, 2029. The award funds research to develop engineered biomaterials and targeted lipid nanoparticle delivery systems designed to enhance lymphatic regeneration in patients with lymphedema—a condition affecting over 35...
- Federal Grant Award Summary Indiana University Indianapolis received a $414,996 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 15, 2025, with completion anticipated by May 31, 2030. This research project investigates the mechanisms of junctional proteins in post-surgical lymphedema, a chronic condition affecting approximately 5-10 million Americans, with secondary lymphedema...
- Federal Grant Award Summary The University of Virginia received an $802,611 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with completion targeted for August 31, 2029. The grant funds the development of advanced cardiac magnetic resonance imaging (CMR) methods to quantify epicardial adipose tissue (EAT) composition and to investigate the relationship between EAT...
- Federal Grant Award Summary The University of Virginia received a $726,452 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion scheduled for April 30, 2029. The grant funds research to model intra- and inter-cellular signaling networks that mediate Transient Receptor Potential Canonical 6 (TRPC6)-dependent cardiac fibrosis. The primary deliverable is the...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the Regents of the University of Michigan a $1.49 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 20, 2025, with a completion date of June 30, 2030. The award funds the development of an in situ micro-rheology technique using ultrasound-responsive nanodroplets to characterize aging thrombi (blood clots) in real-time. The research addresses a...
- Federal Grant Award Summary The University of Southern California received a $808,121 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 15, 2025, with a completion date of February 28, 2029. This research project investigates the role of PIEZO1-controlled PROX1 modification in lymphatic valve formation, focusing on how lymphatic endothelial cells detect and respond to fluid mechanical...
- Federal Project Grant Award Summary William Marsh Rice University received a $491,029 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective June 20, 2025, with a completion date of April 30, 2029. The award funds development of a bioengineered lymphatic regenerating platform designed to treat breast cancer-related lymphedema (BCRL), a chronic condition affecting approximately 40% of breast cancer...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a Project Grant totaling $865,694 (awarded June 5, 2025; completion date April 30, 2029) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on neuropilin-2 (NRP2) signaling and lymphatic function. The research focuses on understanding how NRP2, a transmembrane receptor in lymphatic endothelial cells, functions as a dynamic regulator of...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $1.29M project grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for the period September 1, 2025 through August 31, 2028. The project focuses on developing advanced imaging and analysis tools to enhance lymphoscintigraphy (LSG), the current gold standard...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $534,761 Project Grant to the University of California, Los Angeles (UCLA) under the Cardiovascular Diseases Research program (CFDA 93.837) for the development of magnetoelastic vascular grafts (MVGs). The project, which commenced September 1, 2025, and will conclude June 30, 2029, aims to create an innovative vascular graft platform that simultaneously restores blood flow while enabling wireless,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Virginia a $950,550 Project Grant effective April 1, 2026, through February 28, 2033, under the Cardiovascular Diseases Research program (CFDA 93.837). This award funds a translational research program focused on developing and advancing magnetic resonance imaging (MRI) technologies to visualize the lymphatic system and sodium accumulation in patients with lymphatic diseases, including leg lymphedema, arm lymphedema, and lipedema. The research program delivers three integrated product and service streams: (1) development of imaging outcome measures and understanding disease progression in leg lymphedema patients undergoing micro-surgical repair; (2) design and validation of advanced MRI technologies to observe sodium and lymphatic physiology in arm lymphedema; and (3) basic science investigation into sodium storage mechanisms in lipedema to identify new diagnostic strategies. Collectively, these research activities are intended to produce clinical imaging biomarkers suitable for emerging lymphatic disease clinical trials and to reduce diagnostic time-to-treatment for affected patients.Federal Grant Award Summary
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