Project Grant R35GM167167
- The National Institute of General Medical Sciences awarded the University of Pittsburgh $414,677 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel peptide nucleic acid (PNA) approaches for targeting mitochondrial DNA heteroplasmy in primary mitochondrial diseases. The funded research addresses the lack of approved methods to selectively modify or repair pathogenic mitochondrial DNA variants. The project integrates three complementary...
- The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study mitochondrial stress signaling pathways mediated through communication with other organelles. The research program comprises two projects. The first investigates mitochondrial DNA release triggered by mtDNA damage and its trafficking through the endosomal pathway, which results in innate immune...
- The National Institute of General Medical Sciences awarded Thomas Jefferson University $567,411 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study the mechanisms of lytic granule exocytosis in cytotoxic T-cells. The recipient will investigate how MUNC13 and SEC1/MUNC18 family proteins regulate SNARE-mediated membrane fusion, focusing on the role of lipid-anchored STX11 in granule release. The research uses liposome-fusion assays to dissect...
- The National Institute of General Medical Sciences awarded New York University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a K99/R00 project investigating mitonuclear regulation in Caenorhabditis elegans. The research aims to determine how interactions between mitochondrial and nuclear genomes regulate gene expression and stress responses across tissues. Using natural mitochondrial variation in C. elegans combined with...
- The National Institute of General Medical Sciences awarded Trustees of Boston University $439,148 on March 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a five-year investigation into the regulation of mitochondrial DNA packaging and gene expression. The research develops and applies cutting-edge sequencing technologies to reveal how cells regulate energy production through mitochondrial DNA packaging, expression, and replication. The...
- The National Institute of General Medical Sciences awarded University of Texas at Austin $434,480 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the mechanisms of mitochondrial DNA heteroplasmy quality control. The project investigates how mitochondrial genomes maintain fidelity when both wild-type and mutant mtDNA coexist (heteroplasmy), and how tissue-specific thresholds govern mitochondrial function. The research leverages...
- The National Institute of General Medical Sciences awarded Thomas Jefferson University $431,750 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cellular regulation of mutationally activated G proteins. The research examines how G protein alpha subunits function independently of G protein-coupled receptors when bearing mutations that render them constitutively active. The work addresses signaling and regulation mechanisms of mutant...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded the University of New Mexico Health Sciences Center $517,014 under Project Grant R01GM158808 on June 1, 2026, to investigate the mechanistic basis of selective autophagy mediated by TRIM proteins. The research addresses how TRIM protein family members coordinate the recognition and autophagic degradation of unnecessary or damaged cytoplasmic contents, including proteins and organelles such as mitochondria and lysosomes. The project...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
The National Institute of General Medical Sciences awarded Thomas Jefferson University $392,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on autophagy of mitochondria containing mitochondrial DNA (AUMID). The project investigates the molecular mechanisms that regulate and drive selective autophagy of mitochondria enriched for mtDNA in a cell-type-specific manner, distinct from damage-induced mitophagy. The research will examine how AUMID activation and regulation function, how cell specificity arises, and the impact of AUMID on mitochondrial function and cellular health, with results intended to illuminate mechanisms governing homeostatic mitochondria and mtDNA copy number across diverse cell types. Performance occurs in Philadelphia, Pennsylvania, with a completion date of April 30, 2031. This is a Project Grant under the NIGMS research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $392.5k | 8/17/26 |