Project Grant R35GM165571
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded the University of Virginia $706,860 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the regulation of ceramide-1-phosphate metabolism in cell signaling networks and metabolic reprogramming. The research examines how ceramide-1-phosphate, a bioactive sphingolipid produced by ceramide kinase,...
- The National Institute of General Medical Sciences awarded the University of Virginia $441,474 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how ion channels orchestrate endolysosomal system functions in myeloid phagocytes. The research pursues three complementary directions: characterizing how M7VS (specialized TRPM7-containing vesicles) drive phagosome maturation and endolysosomal homeostasis; dissecting the dual channel-kinase...
- The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin signaling during DNA repair. The research examines how chromatin-modifying enzymes reorganize chromatin structure in response to DNA damage and restore that structure following repair, using histone ADP-ribosylation signaling during DNA excision repair...
- The National Institute of General Medical Sciences awarded Thomas Jefferson University $392,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on autophagy of mitochondria containing mitochondrial DNA (AUMID). The project investigates the molecular mechanisms that regulate and drive selective autophagy of mitochondria enriched for mtDNA in a cell-type-specific manner, distinct from damage-induced mitophagy. The research will...
- The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms underpinning the formation and function of multinucleated cell types, including foreign body giant cells, syncytiotrophoblasts, myofibers, and osteoclasts. The research employs induced pluripotent stem cell modeling to resolve the role of syncytin 1 in multinucleation...
- The National Institute of General Medical Sciences awarded the University of Virginia $425,145 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop integrated microscopy and image processing technologies for long-term three-dimensional fluorescence imaging of bacterial biofilm communities on and within living human epithelial tissues. The project will create imaging and tracking systems capable of measuring single-cell three-dimensional bacterial...
- The National Institute of General Medical Sciences awarded the University of Pittsburgh $414,677 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel peptide nucleic acid (PNA) approaches for targeting mitochondrial DNA heteroplasmy in primary mitochondrial diseases. The funded research addresses the lack of approved methods to selectively modify or repair pathogenic mitochondrial DNA variants. The project integrates three complementary...
- The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the mechanisms of genome integrity maintenance and break-induced replication at repetitive DNA sequences. The research focuses on elucidating how break-induced replication drives genome instability in repetitive DNA regions, particularly telomere maintenance through the alternative lengthening...
- The National Institute of General Medical Sciences awarded the University of Virginia $1.708 million on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define the paralipidome and establish how local lipid nano-environments around membrane proteins regulate their structure and physiology. The project, titled "Defining the Paralipidome: A New Frontier in Membrane Biology," will employ recent technical advances to directly probe the local...
- The National Institute of General Medical Sciences awarded the University of Virginia $415,171 on March 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to design and develop cell-instructive viscoelastic hydrogels for three-dimensional cell culture that enable spatiotemporal control of mechanical properties and stress relaxation to model heterogeneous tissue mechanics during development, disease, and wound repair. The project comprises two themes. Theme 1...
The National Institute of General Medical Sciences awarded the University of Virginia $444,125 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study mitochondrial stress signaling pathways mediated through communication with other organelles. The research program comprises two projects. The first investigates mitochondrial DNA release triggered by mtDNA damage and its trafficking through the endosomal pathway, which results in innate immune signaling when endosomes rupture. Work will identify the mechanisms enabling mtDNA to exit mitochondria into an uncharacterized vesicle facilitating trafficking into endosomal compartments and will screen for proteins necessary for mtDNA exit from mitochondria and its ultimate release from endosomes into the cytosol. The goal is to identify machinery that can be inhibited to block mtDNA release, enabling future in vivo investigation of mtDNA-mediated inflammatory signaling within chronic disease contexts. The second project studies ARL10, a regulatory protein discovered to localize dually to mitochondria and the nucleus, hypothesized as a novel regulator of mitochondrial stress signaling. Performance occurs in Charlottesville, Virginia, with a period of performance through March 31, 2031. This is a Project Grant assistance type. The University of Virginia is the recipient organization.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $444.1k | 7/27/26 |