Project Grant R35GM166587
- The National Institute of General Medical Sciences awarded Arizona State University $2,081,661 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop plasmonic and evanescent scattering microscopy technologies for label-free functional imaging of single molecular and cellular activities. The recipient will advance optical detection methods that measure intrinsic molecular and cellular optical properties without fluorescent or radioactive...
- The National Institute of General Medical Sciences awarded Arizona State University $363,365 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance spin-based quantum sensors for single-cell analysis. The research will develop optically addressable spin-qubit magnetometers to detect biological magnetic fields at the nanoscale, focusing on improving sensor coherence and biocompatibility to enable label-free detection of cellular activities...
- The National Institute of General Medical Sciences awarded Arizona State University $300,000 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate synthetic microbial communities and their ecosystem dynamics. The project develops and characterizes synthetic two-component and higher-order E. coli microbial communities with diverse inter-strain interaction topologies, coupling bacterial toxin-antitoxin systems with quorum sensing to create...
- Federal Project Grant Award Summary Arizona State University received a $413,036 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2027. The award supports the development of a novel single-molecule glycosaminoglycan (GAG) sequencing method using fluorophore-labeled lysosomal enzymes. Glycosaminoglycans are large, linear, sulfated...
- The National Institute of General Medical Sciences awarded $343,351 to Arizona State University on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate plasmid DNA methylation in tissue repair. The research examines the delivery of unmethylated plasmid DNA (uPDNA) possessing differential prokaryotic methylation content to skin for transgene expression and tissue repair applications. Preliminary findings demonstrate that intradermal and...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded Arizona State University $799,995 on August 1, 2026, under the Biological Sciences program (CFDA 47.074) to establish a quantitative framework for understanding reciprocal interactions between biomolecular condensates and cellular growth. The project will use integrated experimental and computational approaches to determine how cellular growth regulates condensate formation, dissolution, and phase-separation...
- The National Institute of General Medical Sciences, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Arizona State University $404,180 on July 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how bacterial predation via the type VI secretion system shapes ecological and evolutionary dynamics in microbial communities. The D'Souza Lab will study T6SS-mediated antagonism in two bacterial...
- The National Institute of Allergy and Infectious Diseases awarded Arizona State University $429,997 on June 12, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to engineer inducible morphotype switching control in Mycobacterium abscessus for investigating infection outcomes and discovering pathophysiological-targeted treatments. The project leverages CRISPR interference (CRISPRi) and anhydrotetracycline-inducible tetr-regulated promoter-operator systems to create...
- The National Institute of General Medical Sciences awarded $376,481 to the University of Arizona on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop bioinspired therapeutic microcarriers that evade immune clearance and enable controlled drug release. The project addresses a critical gap in drug delivery: up to 90 percent of synthetic nano- and microparticle-based therapeutic carriers are cleared from the bloodstream by the immune system and...
- The National Institute of General Medical Sciences awarded the University of Arizona $407,323 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to establish glyoxalase 2 as a viable drug target for treating disease. The research program investigates protein post-translational modifications and their role in metabolic sensing, focusing on lactoyllysine as a novel modification that regulates glycolytic flux and inflammatory signaling. The work employs...
The National Institute of General Medical Sciences awarded Arizona State University $378,995 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to decode the toxicity-efficacy paradox in gene and nucleic acid therapies. Over five years through August 31, 2031, the funded research will generate an integrated atlas of escape-induced toxicities using phosphoproteomics, transcriptomics, and mediator profiling to map how endosomal escape location and payload chemistry stimulate toxicity while identifying druggable convergent nodes. The program will also develop systemic delivery strategies that merge reticuloendothelial system nanopriming with pathway-specific interventions. The research addresses a critical clinical bottleneck: approximately 70 percent of gene therapy trial terminations cite safety or toxicity as the primary reason, often because therapies are dosed below efficacy thresholds to remain tolerable or escalated to efficacious levels that trigger catastrophic toxicities. Work is performed in Tempe, Arizona. Arizona State University's Office of Research and Sponsored Projects Administration (Orspa) serves as the recipient organization, administering the award on behalf of the university's research team.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/26 | ||
| Not listed | $379.0k | 8/20/26 |