Project Grant R35GM166544
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded the University of California, Davis $393,008 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on the regulation of cell fate specification during the regeneration of complex sensory organs. The funded research uses the freshwater apple snail (Pomacea canaliculata) as a model organism to uncover molecular mechanisms driving...
- This National Science Foundation Project Grant award of $726,922 will support research into the convergent evolution of eyes in cnidarians through a collaborative project between the University of California, Santa Barbara and the State of California Controller's Office. The three-year award, made under the Biological Sciences program (CFDA 47.074), aims to advance understanding of evolutionary relationships in medusozoan jellyfish and the independent origins and development of eyes in this...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services, awarded $153,560 to the University of California, Santa Barbara on November 21, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing). The recipient will conduct physiological, molecular, and bioinformatic experiments to determine the role of circadian rhythms in modulating wound healing and whole-body regeneration, with focus on identifying the...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $526,805 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop episomal single-cell reporter assays for measuring the activity of hundreds to thousands of regulatory elements with tissue-specific resolution in whole developing embryos. The research focuses initially on enhancers as critical regulatory elements controlling gene expression timing and...
- The National Institute of General Medical Sciences awarded $441,375 to The Regents of The University of California, doing business as University of California, Berkeley, on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cell and developmental mechanisms of animal responses to intracellular beneficial microbes. The funded research uses the small anemone Aiptasia as a genetically tractable model organism to study the cell biology...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $381,176 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanoscale tools for studying membrane damage and repair and enable intracellular sensing. The project will uncover how cells detect, respond to, and repair damage to their plasma and nuclear membranes, and harness these processes for intracellular sensing. Theme 1 uses...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded the University of California, Los Angeles $433,125 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop imaging-based molecular recording methods that reconstruct the signaling history of individual cells during development. The funded research extends a signal-recording approach that uses regulated CRISPR base editors to generate mutations in engineered genomic target sites at rates...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, San Francisco $562,484 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation visualization and analysis software for multiscale molecular modeling. The recipient will create cutting-edge software tools that integrate visualizations and analyses of molecular structures and related biological information, including...
- The National Science Foundation Division of Environmental Biology awarded The Regents of the University of California, doing business as University of California, Berkeley, $630,979 on July 1, 2026, for collaborative research investigating kleptocnidy in nudibranch gastropods under the Biological Sciences program (CFDA 47.074). The project will generate high-quality genomic, transcriptomic, and single-cell data resources for marine invertebrates to determine whether kleptocnidy—the theft and...
The National Institute of General Medical Sciences awarded the University of California Santa Cruz $425,804 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to establish eyed cnidarians (jellyfish) as model systems for investigating the cellular and molecular mechanisms of eye development and regeneration. The research will employ single-cell sequencing, in situ hybridization, and gene knockdowns to identify the cell types, cell trajectories, and gene expression changes underlying developing and regenerating sensory structures in cnidarians with convergently evolved eyes. The work compares regeneration to development within species to determine whether regenerated eyes arise from identical gene networks and cell lineages as developmentally formed eyes, and compares development and regeneration across cnidarian species to establish the extent to which evolution has converged on the same genes and cell-type trajectories for convergent organs. The research ultimately aims to identify cell types, gene regulatory networks, and signaling pathways critical to regeneration across cnidarians, providing insight into the evolutionary conservation or innovation of regenerative mechanisms in animals. Performance occurs at the University of California Santa Cruz, Santa Cruz, California, with a completion date of July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $425.8k | 8/26/26 |