Project Grant R35GM166288
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $432,850 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational research on protein dynamics and allostery in biomedically important enzymes. The work uses biomolecular simulations to explore conformational dynamics, allosteric regulation, and catalytic function in three enzyme systems: PRIA and TRPC (central to tryptophan biosynthesis and potential...
- The National Institute of General Medical Sciences awarded Georgia Southern University Research & Service Foundation Inc. $142,000 on July 16, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational tools for analyzing actin filament architecture in cryo-electron tomography (cryo-ET) images. The project addresses a critical bottleneck in structural biology: current methods for extracting quantitative morphological data from cryo-ET images...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- The National Institute of Biomedical Imaging and Bioengineering awarded Georgia TECH Research Corp $212,297 on July 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to engineer stress-responsive protein sensors for precision cancer immunotherapy. The recipient will develop synthetic protein circuits that sense and respond to physiological stress states in the tumor microenvironment, specifically hypoxia and...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $426,539 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop AI-driven robotic systems that plan, execute, and interpret automated experiments mapping bacterial pathogen phenotypes and quorum sensing pathways. The work focuses on context-specific cellular networks in streptococci, integrating metabolism and quorum sensing into a quantitative...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $833,955 on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop tools for mapping the glycan-protein interactome using bioorthogonal chemistry and deep learning. The recipient will synthesize and optimize bifunctional ganglioside probes bearing photoaffinity diazirines and click alkyne tags, deliver these probes to human cancer cell lines to capture...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $407,283 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the cellular basis of complex behavior in cichlid fish. The research identifies how natural genetic variation encodes social behavior in the vertebrate brain through context-dependent gene expression in specific cell types. The team will use Lake Malawi cichlids to leverage rapid...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $607,227 on July 1, 2026, under CFDA 93.859 (Biomedical Research and Research Training) to investigate transcript RNA-mediated mechanisms in the end-joining repair of DNA double-strand breaks. The funded research systematically uncovers how RNA transcripts bridge broken DNA ends and facilitate repair through non-homologous end joining and microhomology-mediated end joining pathways in human cells. Aim 1...
- The Georgia Tech Research Corporation was awarded a $1,077,799 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences on September 1, 2021 to complete work by August 31, 2025. The grant falls under the Biological Sciences program (CFDA 47.074), which aims to promote progress in the biological sciences and strengthen the nation's scientific enterprise through increasing knowledge and enhancing understanding of major problems. Specifically, the grant will...
- The National Institute of General Medical Sciences awarded Florida Institute of Technology Inc. $527,392 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop nanodiamond quantum sensing platforms for measuring redox dynamics in live cells. The Usselman Lab will engineer chemogenetic systems using D-amino acid oxidase to generate hydrogen peroxide with spatial and dose control in mammalian cells, then quantify redox dynamics using ratiometric...
The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $421,857 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds development of quantum and nanosensing technologies combined with artificial intelligence to investigate autophagic pathways and lysosomal dysregulation in living systems. The research employs precision synthetic chemistry, nanoscale engineering, spectroscopy, and machine learning to monitor cellular processes with enhanced sensitivity and selectivity. Preliminary work using pH-responsive nanosensors has demonstrated that mTORC inhibition promotes lysosomal hyperacidification and identified a correlation between lysosomal acidification and autophagy initiation; the project will expand to multiplexed sensing of additional ionic and metabolic parameters to further elucidate lysosomal signaling roles and identify molecular vulnerabilities in dysregulated autophagy. Performance occurs at Georgia Institute of Technology in Atlanta, Georgia, with a period of performance from August 1, 2026, through July 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $421.9k | 7/27/26 |