Project Grant R35GM166249
- The National Institute of General Medical Sciences awarded Marshall University Research Corporation $147,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect G protein versus β-arrestin-mediated signaling pathways in the cannabinoid receptor 1 (CB1). The research develops and characterizes a phosphorylation-deficient CB1 receptor that cannot signal through β-arrestin but retains G protein signaling capacity, enabling distinction between...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded the University of Miami $501,165 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support structural and biophysical research on three human membrane proteins with significance to cardiovascular health, hemostasis, and inflammation. The funded research determines the structures and functional mechanisms of connexin channels, which coordinate electrical and metabolic activity in cardiac...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded the University of Cincinnati's Sponsored Research Services Division $756,933 on April 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and functional characterization of transforming growth factor beta (TGFβ) superfamily signaling and regulation. The research employs structural biology, computational biology, biophysics, and cell-based signaling assays to investigate...
- The National Institute of General Medical Sciences awarded the University of Missouri System $418,114 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop orthogonal strategies for chemoselective peptide macrocyclization. The funded work develops two new chemical methods for cyclizing peptides: a sulfur(VI)-fluoride exchange (SUFEX)-mediated cyclization method selective for tyrosine and a light-mediated cyclization method selective for lysine....
- The National Institute of General Medical Sciences awarded the University of California, San Diego $369,347 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct high-resolution structural analysis of megasynthases by cryo-electron microscopy. The project develops molecular tools and probes to enable structural visualization of protein-protein interactions within carrier protein-dependent biosynthetic pathways, including fatty acid synthase,...
- The National Institute of General Medical Sciences awarded Virginia Polytechnic Institute & State University $410,605 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop accurate and efficient solvent models for molecular simulations with applications in structure-based drug design and biomolecular research. The project focuses on advancing water model development for atomic-level computational simulations, addressing accuracy and...
- The National Institute of General Medical Sciences awarded Worcester Polytechnic Institute $554,599 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on how neuropeptides and monoamines establish sex-specific behavioral responses in the nematode Caenorhabditis elegans. The project will define the mechanisms by which NLP-3 neuropeptides and serotonin modulate a shared neural circuit to create sex-divergent avoidance behavior in...
- The National Institute of General Medical Sciences awarded the University of Virginia $441,474 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how ion channels orchestrate endolysosomal system functions in myeloid phagocytes. The research pursues three complementary directions: characterizing how M7VS (specialized TRPM7-containing vesicles) drive phagosome maturation and endolysosomal homeostasis; dissecting the dual channel-kinase...
The National Institute of General Medical Sciences awarded West Virginia University Research Corporation $345,650 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural and mechanistic studies of receptor guanylyl cyclases, with research focused on elucidating ligand specificity and activation mechanisms of GC-B and GC-C subtypes. The research builds on previously determined cryo-electron microscopy structures of GC-A and extends investigation to GC-B, activated by C-type natriuretic peptide and relevant to skeletal growth disorders, and GC-C, implicated in secretory diarrhea and gastrointestinal regulation. The work addresses long-standing barriers to understanding these single-pass transmembrane receptors—their tissue-specific expression, low endogenous abundance, and conformational flexibility—with the goal of enabling therapeutic targeting of receptor guanylyl cyclases implicated in hypertension, skeletal dysplasia, secretory diarrhea, and retinal degeneration. Performance will take place in Morgantown, West Virginia, from September 1, 2026, through April 30, 2031. This is a Project Grant, the standard assistance type under NIGMS's portfolio-based funding approach that prioritizes investigator-initiated research of high scientific merit.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $345.7k | 8/14/26 |