Project Grant R35GM165835
- The National Institute of General Medical Sciences awarded Boston Children's Hospital $2.563 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to expand the biological capabilities of image-based transcriptomics by targeting short, homologous, and synthetic transcripts. The award funds development of multiplexed error-robust fluorescence in situ hybridization (MERFISH) methodology to overcome three key limitations of current image-based...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover novel antimicrobial molecules from clostridial biosynthesis. The project characterizes cobalamin-dependent radical S-adenosylmethionine enzymes fused with non-ribosomal peptide synthetase adenylation domains found in clostridial genomes. The recipient will conduct biochemical characterization of these...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $464,032 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for mapping intercellular circuits governing complex tissues, specifically mucosal epithelia in the intestine, airway, nose, urogenital tract, and related barrier surfaces. The project addresses two key analytical challenges: uncovering intercellular regulatory signals that...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (Massachusetts General Hospital) $444,000 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop secreted genetically encoded fluorescent biosensors for in vivo extracellular imaging. The project will create a toolkit of biosensors across four research areas: imaging extracellular matrix structures by conjugating fluorescent proteins to lectins and...
- The National Institute of General Medical Sciences awarded Northeastern University $434,000 in Project Grant R35GM162269 on March 2, 2026, to develop integrated mass spectrometry strategies for characterizing metabolite-protein cross-regulation in cellular metabolism. The recipient will apply mass spectrometry-based methods to simultaneously probe metabolites and proteins in the cellular context, bridging a gap in current research that has typically focused on either metabolites or proteins...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $899,250 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new computational-experimental approaches for measuring and modeling gene expression trajectories at the single-cell level. The research integrates experimental systems biology and genomics with machine learning and data science to track RNA production, processing, and degradation rates....
- Federal Project Grant Award Summary Northeastern University received a $673,600 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through July 31, 2028. The award supports development of programmable RNA-based sensors that detect integrated changes in both messenger RNA (mRNA) and microRNA (miRNA) to enable in...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded 37Degrees, Inc. $360,247 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type: Project Grant). The award funds development of photoacoustic microscopy systems for non-destructive, three-dimensional imaging of live and incubated engineered tissue. The project addresses a critical gap in...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $269,071 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and apply cryo-electron microscopy and cryo-electron tomography methods for visualizing protein machine assembly, function, and regulation at high resolution. The work emphasizes development of the CryoDRGN and TomoDRGN software ecosystem to enable structural analysis of complex samples in...
The National Institute of General Medical Sciences awarded Northeastern University $440,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop IMAGE-SEQ, a platform integrating high-resolution in vivo optical imaging with spatially resolved single-cell transcriptomics. The award funds three major expansions of the technology: integration with single-cell proteomics to capture protein-level signaling events and define how proliferative states shape intercellular communication in bone marrow; adaptation of IMAGE-SEQ for use in brain tissue to track immune cell dynamics; and extension of the platform beyond mouse bone marrow to additional tissues and vertebrate systems. These advances aim to overcome current limitations of IMAGE-SEQ, which is optimized for RNA sequencing and paired with confocal and two-photon microscopy offering limited penetration depth in scattering tissues. Work is performed in Boston, Massachusetts. The award period runs through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.0k | 8/26/26 |