Project Grant R35GM165655
- The National Institute of General Medical Sciences awarded the University of Florida $411,407 on August 15, 2026, to develop a bioanalytical platform for monitoring and modeling sepsis immunopathology under the Biomedical Research and Research Training program (CFDA 93.859). The funded research establishes an integrated platform to capture ultrasensitive, longitudinal biochemical monitoring of immune effectors in sepsis patients and develop dynamic disease models linking biochemical trends to...
- The National Institute of General Medical Sciences awarded Mayo Clinic Jacksonville $462,410 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to validate sepsis patient subphenotypes defined by lipoprotein and lipid metabolism profiles and assess their therapeutic utility in precision medicine approaches. The research addresses dysregulated lipoprotein and lipid metabolism in sepsis by validating two novel clinical subphenotypes—hypolipoprotein...
- The National Institute of General Medical Sciences awarded Duke University $446,410 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, R01GM163225) to develop and validate statistical methods for identifying disease subtypes in patient populations, with application to sepsis. The project develops three classes of Bayesian statistical approaches designed to address limitations in standard clustering techniques: Bayesian multiview pyramids to handle...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $123,309 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for improving sepsis diagnosis through plasma metagenomic sequencing. The research addresses the challenge of timely and accurate sepsis diagnosis in critically ill patients by analyzing microbial and host cell-free DNA (cfDNA) in blood plasma. Current diagnostic...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $411,475 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026, to engineer a multiplexed biomaterial-based bioluminescent biosensor platform for real-time sepsis diagnosis and precision immunotherapy guidance. The recipient will develop a rapid ex vivo biosensor using biomaterial-immobilized complementation antibody pairs to dynamically sense proteomic...
- The National Institute of General Medical Sciences awarded The Washington University $359,227 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop graph neural networks and longitudinal mediation analysis methods for early detection of hospital-onset sepsis and identification of modifiable risk factors. The project investigates system-level hospital characteristics—including hospital organization, nursing workload, and healthcare personnel...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Michigan $100,228 on February 13, 2027, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop engineered cell-based systems that detect and treat sepsis through synthetic receptors targeting alarmin proteins S100A8 and S100A9. The project will explore two complementary cell engineering strategies: engineering cells to constitutively secrete therapeutics that modulate...
- The National Institute of Allergy and Infectious Diseases awarded Yale University $192,330 on June 11, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of intestinal microbiota in sepsis mortality. The project will elucidate mechanisms by which gut microbial dysbiosis influences sepsis outcomes through a five-year research effort running through May 31, 2031, at Yale's New Haven, Connecticut location. The research combines microbiota...
- The National Institute of Allergy and Infectious Diseases awarded the University of Florida $230,250 on April 17, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop an artificial intelligence-driven computational framework for predicting Kaposi's sarcoma-associated herpesvirus (KSHV) protein interactions with human host proteins, with emphasis on identifying viral proteins that suppress cGAS-STING immune signaling. The project combines deep learning and...
- The National Institute of General Medical Sciences awarded the University of South Florida $474,102 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct synthetic biology and genome engineering of polyketide natural products, develop bioactive metabolites from Antarctic marine invertebrates and deep-sea organisms, synthesize chemical analogs to modulate toxicity and enhance drug-like properties, and advance compound development initiatives...
The National Institute of General Medical Sciences awarded the University of Florida $387,845 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop a personalized sepsis-risk engine using explainable artificial intelligence and in vitro validation. The research integrates multimodal electronic health record data with high-dimensional omics and mechanistic modeling to identify host pathways that convert neutropenic infection into sepsis and enable real-time, patient-specific risk prediction. Over the five-year performance period through June 30, 2031, the team will employ machine learning models to predict sepsis risk based on host conditioning and early biomarkers, develop coupled mechanistic model systems to understand cellular and molecular events driving sepsis progression, and use multi-modal data, mathematical modeling, and in vitro culture systems to reveal how host environment reshapes cellular phenotypes. The work addresses chemotherapy-induced neutropenia, which elevates mortality among cancer patients more than twofold and is currently poorly predicted in clinical trials that fail to account for comorbidities and complex patient environments. The research is performed in Gainesville, Florida.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $387.8k | 8/20/26 |