Project Grant R35GM165598
- The National Institute of General Medical Sciences, an operating division of the Department of Health and Human Services National Institutes of Health, awarded Arizona State University $404,180 on July 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how bacterial predation via the type VI secretion system shapes ecological and evolutionary dynamics in microbial communities. The D'Souza Lab will study T6SS-mediated antagonism in two bacterial...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $432,850 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational research on protein dynamics and allostery in biomedically important enzymes. The work uses biomolecular simulations to explore conformational dynamics, allosteric regulation, and catalytic function in three enzyme systems: PRIA and TRPC (central to tryptophan biosynthesis and potential...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $393,500 on August 24, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how commensal gut protists shape microbiome community ecology and function. Over five years through April 30, 2031, the Lind Laboratory at Georgia Tech will examine gut protist metabolism, identify nutritional inputs and outputs, annotate metabolic gene function, and determine how protist...
- The National Institute of General Medical Sciences awarded Texas State University $401,250 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to study the mechanisms of intergenomic epistasis and environmental context in animal-microbe symbioses. Over the five-year performance period through April 30, 2031, the research will use the Aiptasia anemone and its photosynthetic algal symbiont as a model system to characterize how host and symbiont genotypes...
- The National Institute of General Medical Sciences awarded $441,375 to The Regents of The University of California, doing business as University of California, Berkeley, on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on cell and developmental mechanisms of animal responses to intracellular beneficial microbes. The funded research uses the small anemone Aiptasia as a genetically tractable model organism to study the cell biology...
- The National Institute of General Medical Sciences awarded Georgia State University Research Foundation Inc. $434,729 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on bacteriophage gene essentiality and infection dynamics across environmental contexts. The award funds research to map phage gene function and track infection dynamics using complementary molecular approaches. The work will exploit DNA mismatch-repair deficient...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $407,283 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the cellular basis of complex behavior in cichlid fish. The research identifies how natural genetic variation encodes social behavior in the vertebrate brain through context-dependent gene expression in specific cell types. The team will use Lake Malawi cichlids to leverage rapid...
- This Project Grant award from the National Science Foundation's (NSF) Division of Molecular and Cellular Biosciences, under the Biological Sciences program (CFDA 47.074), provides $833,999.00 to Georgia Tech Research Corporation (Georgia TECH) to investigate how defined microbiomes respond to viruses over short and long timescales. The project aims to test the hypothesis that robust microbiome functions are promoted by microbial communication systems and costs of virus resistance. This...
- The National Science Foundation Division of Environmental Biology awarded Temple University $799,032 on July 1, 2026, under the Biological Sciences program (CFDA 47.074) to investigate the molecular mechanisms by which animal hosts recognize and selectively recruit specific microbial symbionts. The research uses the Siphamia-Photobacterium mandapamensis symbiosis—a partnership between a coral reef fish and luminous bacterium acquired early in host development—as a model system to elucidate how...
- The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $421,857 under the Biomedical Research and Research Training program (CFDA 93.859) on August 1, 2026. The award funds development of quantum and nanosensing technologies combined with artificial intelligence to investigate autophagic pathways and lysosomal dysregulation in living systems. The research employs precision synthetic chemistry, nanoscale engineering, spectroscopy, and machine learning to monitor...
The National Institute of General Medical Sciences awarded Georgia TECH Research Corp $382,507 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support predator-prey dynamics research in a complex animal microbiome led by Dr. Lauren Speare. The research investigates microbial predator-prey interactions and their consequences for animal hosts using a tripartite system comprising the obligate predatory bacterium Halobacteriovorax marinus, the marine pathogen Vibrio coralliilyticus, and stony coral Acropora cervicornis. The laboratory examines factors governing bacterial susceptibility to predation, the role of community diversity in predation dynamics, and pathogen transmission mechanisms between hosts. The system permits bacteria to colonize through natural infection routes, allows coral fragments to enable genetic and life history replication across treatments, permits repeated non-destructive sampling of infection sites, and facilitates genetic manipulation of both microbes. Work is performed in Atlanta, Georgia, with a period of performance extending through May 31, 2031. The project aims to elucidate mechanisms underlying microbial predation within animal tissue to inform targeted, disease-specific manipulation of animal microbiome community composition, function, and health using bacterial predators as control agents.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $382.5k | 7/27/26 |