Project Grant R35GM165433
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $246,263 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research into post-transcriptional regulatory networks and the integrated stress response (ISR). The work will comprehensively characterize the cofactors engaged by regulatory RNA-binding proteins and...
- The National Institute of General Medical Sciences awarded $344,359 to the University of California, Los Angeles on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on programmable RNA materials for structure, function, and applications. The research, led by Principal Investigator Jaimie Marie Stewart in UCLA's Department of Bioengineering, establishes design rules and platform technologies for programmable RNA materials that are...
- The National Institute of General Medical Sciences awarded the University of California, Merced $400,910 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct computational modeling of RNA polymerase II elongation complex dynamics. The project uses molecular dynamics simulations and computational techniques including enhanced simulation methods, machine learning, and deep learning algorithms to study the elongation stage of transcription. The...
- The National Institute of Allergy and Infectious Diseases awarded The University Corporation $147,500 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct a multi-scale study of antimicrobial peptide action in non-standard bacterial growth states. The project addresses how antimicrobial peptides (AMPs)—immune-derived molecules that kill bacteria by disrupting membranes and modulate host immune responses—perform under physiologically relevant...
- The National Science Foundation Division of Molecular and Cellular Biosciences awarded the University of California, San Diego $800,000 on June 15, 2026, under the Biological Sciences program (CFDA 47.074) to systematically identify, functionally characterize, and solve high-resolution structures of RNA tertiary motifs in human cells. The research addresses a significant gap in understanding human gene regulation by using innovative chemical probing technology to discover and visualize...
- The National Institute of General Medical Sciences awarded $422,688 to the Regents of the University of California at Riverside on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing 93.859). The award funds basic research on cell signaling through the primary cilium, a microtubule-based organelle that functions as the cell's signaling hub. The research addresses how the primary cilium senses environmental signaling cues and transduces...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $456,500 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to explore RNA polymerase dynamics and regulatory architecture across divergent bacterial species. The recipient will develop and apply a new sequencing platform that enables purified RNA polymerase to transcribe entire bacterial genomes under defined biochemical conditions, with...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $507,265 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct design and mechanistic investigations of metalloenzymes and metalloproteins. The award funds research combining top-down study of natural metalloenzymes with bottom-up design of artificial ones. The primary focus is nitrogenase, the only known biological system capable of...
- The National Institute of General Medical Sciences awarded The Regents of the University of California at Riverside $923,313 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support cellular programming research using plant photoreceptor signaling models. The project interrogates the function of subnuclear membraneless organelles called photobodies in cell signaling and nuclear gene regulation, and the regulatory mechanisms of organellar gene...
The National Institute of General Medical Sciences awarded The University Corporation $405,625 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize thermoregulatory RNA elements in bacteria, phages, chloroplasts, and mitochondria. The funded work expands discovery and characterization of thermoregulatory RNAs—structured RNA elements that respond to heat stress—across prokaryotic and organellar genomes over five years. A major focus targets bacterial pathogens, where RNA thermometers regulate virulence genes that drive infection and disease; uncovering these elements will reveal new RNA-based targets for antibiotic development. The research identifies novel thermoregulatory RNA classes, uncovers transcriptional thermoregulatory elements called thermoterms, and tests thermoregulatory RNA activity to establish a framework for understanding how RNA structures mediate microbial and organelle responses to heat stress. In parallel, the work develops synthetic thermoregulatory RNAs as genetic tools providing temperature-dependent control of gene expression. The University Corporation is a non-profit auxiliary organization of California State University, Northridge, operating as the research administration entity for CSUN. Work is performed in Northridge, California. The project period runs through May 31, 2031. This award supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $405.6k | 7/23/26 |