Project Grant R35GM165366
- The National Institute of General Medical Sciences awarded The Medical University of South Carolina $315,417 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to define molecular mechanisms of hypoxia-induced fibroblast migration during wound healing. The research identifies how low-oxygen conditions rewire cytoskeletal dynamics to increase fibroblast migration into wound tissue, a rate-limiting step in scar formation. The study focuses on PIM1 kinase as a...
- The National Institute of General Medical Sciences awarded the University of New England $390,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to probe cell signaling complexity in wound healing using engineered protein materials. The recipient will investigate how a protein's molecular environment influences its function and how information flows through protein-ligand interactions using engineered proteins and protein-based materials. The work...
- The National Institute of General Medical Sciences (part of the National Institutes of Health, Department of Health and Human Services) awarded $393,800 to the Terasaki Institute for Biomedical Innovation on September 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop immunomodulatory nanofibrous modular aerogels for chronic wound healing. The research addresses chronic wounds affecting approximately 6.5 million Americans by combining three engineered...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $409,941 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on reprogramming cells for repair of chronic wounds. The research program centers on four investigative questions about how T-cell phenotypes contribute to inflammatory dysregulation in chronic wounds, whether T-cells can be reprogrammed to mitigate inflammation and resolve...
- The National Institute of General Medical Sciences (NIGMS), part of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Dallas $435,875 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Assistance Listing) to investigate how tissue-specific progenitor cell fate is governed by mesenchymal progenitors and sympathetic neurons during adult tissue regeneration. The recipient will use the postnatal mouse...
- The National Institute of General Medical Sciences awarded $498,000 to Trustees of Tufts College on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support research elucidating the epigenetic regulation of extracellular matrix and virus-induced fibroblast activation. The project investigates how epigenetic mechanisms control the sustained activation of fibroblasts into myofibroblasts during fibrotic disease, focusing on the role of BRG1...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $116,005 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support molecular research on neutrophil reverse migration in wound healing. The award funds the K99 phase of a study examining neutrophil subpopulations and their role in inflammation resolution. The research identifies key neutrophil subpopulations involved in reverse migration, tracks their...
- Federal Grant Award Summary The University of Virginia received a $2.16 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This award supports fundamental biomedical research investigating the mechanisms regulating inflammatory fibroblasts in wound healing. The project addresses a critical gap in understanding immune-stromal crosstalk...
- The National Institute of General Medical Sciences awarded Rice University $393,665 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanical memory of cell migration in confined spaces and its relationship to cellular metabolism. The research examines how cells develop metabolic and migration memory when navigating confined microenvironments, and how biomaterial architecture can be engineered to harness this relationship to drive...
- The National Institute of General Medical Sciences awarded Howard University $190,291 for a Project Grant on September 1, 2026, to decode cargo sorting and selection mechanisms in mesenchymal stem cell-derived extracellular vesicles for next-generation therapeutic design. The research investigates how MSCs regulate the molecular content of extracellular vesicles, focusing on integrin-mediated signaling and its influence on cargo selection. The project employs engineered peptide-polymer scaffolds...
The National Institute of General Medical Sciences awarded $451,000 to The University of Texas MD Anderson Cancer Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect the role of extracellular vesicles and matrix in wound healing. The research identifies mechanisms by which fibroblasts respond to tissue injury through extracellular vesicle cargo packaging and extracellular matrix remodeling. The project uses genetically engineered mouse models to determine how fibroblasts orchestrate intercellular signaling during wound repair and to functionally characterize fibroblast-mediated extracellular matrix deposition and remodeling. The work addresses dysfunctional fibroblast activation in chronic non-healing wounds, where dysregulated intercellular signaling and altered extracellular matrix secretion and remodeling prevent effective tissue repair. Performance occurs in Houston, Texas, with a period of performance extending from September 1, 2026, through April 30, 2031. This is a Project Grant, an assistance type under NIGMS's mission to support basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $451.0k | 8/25/26 |