Project Grant R01GM160881
- The National Institute of General Medical Sciences (NIGMS) awarded William Marsh Rice University $405,251 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, Project Grant R35GM166390) to develop a broad-spectrum DNA recorder—a synthetic biology tool enabling cells to create permanent DNA records of transient biological events such as signaling pathway activation in living organisms. The research addresses three project areas: engineering modular,...
- The National Institute of General Medical Sciences awarded Texas A&M Engineering Experiment Station $394,917 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop advanced label-free microscopy methods linking cell structure to mechanobiology. The work focuses on quantitative phase imaging and holotomography as nondestructive, non-contact tools for visualizing cytoskeletal structure and predicting cell viscoelasticity in live, unlabeled cells....
- The National Institute of General Medical Sciences awarded $451,000 to The University of Texas MD Anderson Cancer Center on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect the role of extracellular vesicles and matrix in wound healing. The research identifies mechanisms by which fibroblasts respond to tissue injury through extracellular vesicle cargo packaging and extracellular matrix remodeling. The project uses genetically engineered...
- The National Institute of General Medical Sciences awarded the University of Texas at Dallas $1.928 million on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for a project grant investigating how cellular metabolism shapes embryonic development. The funded research integrates advanced imaging, genetic tools, and single-cell sequencing in the chordate model Ciona to examine how metabolic rewiring orchestrates gene regulatory networks during...
- The National Institute of General Medical Sciences awarded the University of Wisconsin–Madison $124,929 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to fund research on how epithelial architecture regulates amoeboid migration strategies in vivo. The research examines cell migration through tissues, with focus on leukocyte movement within epithelial layers. Work uses intravital imaging in zebrafish to characterize how mechanical confinement drives...
- The National Institute of General Medical Sciences awarded Texas A&M University System Health Science Center $418,952 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop light-controlled tools and genetically encoded sensors for studying calcium signaling at membrane contact sites in living cells. The research program integrates three directions. First, the team will engineer light-activated actuators to control organelle positioning and...
- The National Institute of General Medical Sciences awarded Baylor College of Medicine $416,000 on July 20, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type Project Grant) to investigate intrinsically disordered region-mediated interaction networks linking chromatin state to RNA export. The research addresses molecular mechanisms by which intrinsically disordered regions in RNA export factors ensure efficient export of highly transcribed genes,...
- Yale University received a $669,737 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for research on the mechanics of convective cell motion. The two-year project, which commenced September 1, 2025 and concludes August 31, 2027, supports fundamental basic research investigating how cellular populations move collectively through tissue-level mechanical forces such as surface tension and pressure...
- The National Institute of General Medical Sciences awarded the University of California, Davis $432,417 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how linear and nonlinear mechanical forces in the extracellular matrix regulate cell metabolism through mechanotransduction pathways. The research uses induced pluripotent stem cells in both single-cell and organoid cultures within three-dimensional polymeric hydrogel systems to...
- The National Institute of General Medical Sciences awarded Baylor College of Medicine $440,000 on February 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the physical principles governing nucleolar condensates and their role in ribosome biogenesis. The research develops quantitative microscopy methods to determine how nucleolar composition changes in response to cellular stimuli and during cellular transitions. The work tests the hypothesis...
The National Institute of General Medical Sciences awarded Rice University $393,665 on September 4, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanical memory of cell migration in confined spaces and its relationship to cellular metabolism. The research examines how cells develop metabolic and migration memory when navigating confined microenvironments, and how biomaterial architecture can be engineered to harness this relationship to drive enhanced migration. The work employs microfabricated platforms to control cell migration paths and confinement, single-cell biosensors to measure metabolic activity, molecular constructs to tune cell-matrix adhesion, and organoid models of wound healing. Three aims investigate the mechanisms by which confinement confers migration and metabolic memory; define the biomaterial parameter space that primes cells for migration, with assays conducted in vitro, ex vivo, and in vivo including in a human skin wound healing model; and use an orthogonal approach combining metabolic disruption through pharmacological agents with migration ability testing to determine the governing parameters linking metabolism and migration. Performance occurs in Houston, Texas. The period of performance extends from September 4, 2026, through May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $393.7k | 9/3/26 |