Project Grant R35GM164190
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $469,700 for a Project Grant (R35GM163873) on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The research program investigates the fundamental mechanisms of chloride channels and transporters, specifically focusing on structure-function relationships, gating mechanisms, and regulatory processes in the CLC protein family. The work emphasizes how subtle...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $423,500 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to dissect the molecular mechanisms of membrane protein complex assembly at the human endoplasmic reticulum. The project investigates how thousands of membrane proteins find correct binding partners to assemble into functional complexes of defined stoichiometry, using voltage-gated ion channels...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $421,456 on July 1, 2026, to discover and engineer biosynthetic pathways from plant natural products for therapeutic development under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research to characterize complete biosynthetic pathways of clinically approved plant-derived...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $364,910 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer enzyme-responsive elastin-like polypeptides that direct biomolecular phase behavior for applications in regenerative tissue engineering, controlled drug delivery, and scalable therapeutic biomolecule production. The recipient will develop stimuli-responsive biopolymers triggered by...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $125,000 under the Biomedical Research and Research Training program (CFDA 93.859) on May 1, 2026, to develop membrane-centric proximity labeling approaches for mapping lipid-protein and protein-protein networks in live cells. The work targets transient and context-dependent membrane interactions that remain difficult to study with conventional tools. The recipient will engineer conditionally...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $236,736 on August 9, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemically induced proximity methodology for rewiring nucleosome engagement patterns. The project runs through April 30, 2028, with work performed in Palo Alto, California. The funded research applies bivalent molecules that bind and bring together two biomolecules to promote the...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $1.924 million on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate how nuclear mechanical properties regulate cell functions independently of gene expression. The research examines whether and how mechanical properties of the nucleus—including size, stiffness, and integrity—control essential cellular processes such as migration, proliferation,...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $152,600 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on January 18, 2027, to conduct research decoding mechanisms and signaling by an S-acylated isoform of calcineurin. The award funds a fellowship project investigating how S-acylation and calcium/calmodulin signaling coordinate to regulate CNAB1's membrane localization, catalytic activity, and substrate...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for Project Grant K99GM163015, which runs through August 31, 2028. The award funds research into mechanisms of ionic stress sensing and mitigation during mammalian osmoadaptation. The investigator will employ CRISPR base editing screens to define sequence features in the transcription factor NFAT5...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $616,000 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes for mapping spatial proteomes in living cells. The research aims to engineer and optimize FLEXID and LACCID, two proximity labeling enzymes designed to overcome limitations of existing methods like APEX and TURBOID in specificity, sensitivity, and...
The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $431,563 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemical tools for studies of ion channel function and physiology. The work focuses on creation of small-molecule chemical agents—including modified natural toxins, fluorescence imaging probes, photochemical cross-linking agents, and subtype-specific inhibitors—to enable investigation of sodium and chloride ion channels in living cells and tissue. The research aims to characterize how channel localization, expression levels, and post-translational modifications change in response to nerve injury, inflammatory factors, glial cells, and pH variation. Parallel efforts target understanding of channel dynamics and allosteric modulation through engineered channels and chemical synthesis of toxin derivatives. Performance occurs in Palo Alto, California, with a period of performance through June 30, 2031. The award is classified as a Project Grant under the assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.6k | 8/21/26 |