Project Grant R35GM164164
- Federal Grant Award Summary The University of Massachusetts received a $396,854 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports the development of a nanopore tweezer toolkit designed to analyze kinase structural dynamics and screen allosteric inhibitors. This research leverages protein nanopore sensor technology to...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $127,567 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of nuclease-based bacterial immunity systems. The research, carried out in Cambridge, Massachusetts, through August 31, 2028, combines genetic and molecular biology approaches with training in biochemistry, structural biology, and computational methods to dissect how...
- The National Institute of General Medical Sciences awarded Northeastern University $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover novel antimicrobial molecules from clostridial biosynthesis. The project characterizes cobalamin-dependent radical S-adenosylmethionine enzymes fused with non-ribosomal peptide synthetase adenylation domains found in clostridial genomes. The recipient will conduct biochemical characterization of these...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $437,036 on June 1, 2026, for genomic enzymology research to decipher bacterial membrane-associated glycan assembly under the Biomedical Research and Research Training program (CFDA 93.859). The funded work identifies and assigns functional signatures for substrate specificity in phosphoglycosy transferase and glycosyltransferase enzymes to enable glycan composition inference at the protein sequence...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant totaling $457,500.00 under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Massachusetts Boston. The grant, with a performance period from September 17, 2024 to August 31, 2027, aims to systematically identify chemical processes and reactions that show promise when initiated under high hydrostatic pressure (HHP) conditions. The research will involve a combination of...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) beginning September 1, 2025 and concluding August 31, 2030. This award supports research on causal inference methodologies for reconstructing gene regulatory networks (GRNs) at the single-cell level. The project will develop advanced computational...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $438,788 in project grant funding on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on microbial manipulation of eukaryotic membranes. The research examines how bacteria including Listeria monocytogenes and Rickettsia parkeri manipulate host cell membranes to disseminate through tissues and cross cellular compartments. The study focuses...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $393,689 in project grant funding on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research defining mechanisms that couple nutrient sensing to functional programs in non-malignant mammalian cells. The...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Massachusetts $539,219 on June 9, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop polymeric lysosome-targeting chimeras (POLYTACS), a biomaterials platform for cell-specific degradation of membrane proteins. The award funds research to create a versatile POLYTACS platform enabling targeted protein degradation of...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $435,829 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support investigation of gut-brain communication mechanisms underlying behavioral state transitions. The research, led by the Alkema Lab, examines how internal states and environmental cues integrate to regulate behavior in C. elegans, using the organism's defined neural circuits, genetic...
The National Institute of General Medical Sciences awarded the University of Massachusetts $2.35 million on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate non-specific electrostatic interactions of biological macromolecules in physiological and pathological processes. The project examines how highly charged polycationic and polyanionic biomacromolecules — including heparin, neutrophil extracellular traps, and other polymeric species — drive processes such as hemostasis, thrombogenesis, viral and bacterial infections, autoimmune disorders, and innate immune responses through electrostatic interactions. The research also explores the therapeutic application of bismuth-based compounds against antibiotic-resistant gastric pathogens, with emphasis on understanding how charge density enables molecular promiscuity and functional versatility across hundreds of physiological partners. Performance occurs at the University of Massachusetts in Hadley, Massachusetts through July 31, 2030. This is a Project Grant, a standard assistance mechanism under NIGMS supporting investigator-initiated basic research that advances understanding of human health and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.4m | 7/21/26 |