Project Grant R35GM163945
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $419,939 on August 1, 2026, to conduct live-cell super-resolution imaging research on enhancer-mediated gene bursting under the Biomedical Research and Research Training program (CFDA 93.859). The research characterizes transcriptional condensates—assemblies of RNA Polymerase II, Mediator, and transcription activators—in mouse embryonic stem cells and examines how they regulate target gene expression...
- The National Institute of General Medical Sciences awarded The University of Texas Southwestern Medical Center $456,500 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of lysosome GPCR signaling in metabolic regulation. The recipient will employ biosensors, omics approaches, biochemistry, and cell biology tools to map signaling cascades of LYCHOS (lysosomal cholesterol signaling), a lysosome-resident G...
- The National Institute on Aging awarded Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, $479,579 under the Aging Research program (CFDA 93.866) on August 15, 2026, to investigate synaptic and metabolic alterations associated with TDP-43 proteinopathy in amyotrophic lateral sclerosis and frontotemporal dementia. The research identifies how mislocalization of TDP-43 protein from the nucleus to the cytoplasm disrupts synaptic vesicle cycling, RNA processing,...
- The National Institute of General Medical Sciences awarded the Regents of the University of Michigan $425,916 under the Biomedical Research and Research Training program (CFDA 93.859) on June 1, 2026. The award funds a five-year investigation into the mechanisms of lysosomal resilience, repair, and removal. Research will examine how cells sense acute changes in lysosomal membrane structure and coordinate restorative responses, including how local membrane remodeling and reinforcement by ESCRT...
- The National Heart, Lung, and Blood Institute awarded Pennsylvania State University (operating as Penn State Milton S. Hershey Medical Center) $777,903 on August 4, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop software tools and statistical methods for dissecting functional and environment-dependent effects of lipid-associated genetic variants. The award funds development of novel computational approaches to integrate experimental genomic data and refine...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $750,554 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms and control of oxygen and carbon-hydrogen activation within enzyme architectures. The award supports a five-year project through March 31, 2031, with performance at Penn State's State College, Pennsylvania campus. The research program examines three classes of metalloenzymes that...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $432,575 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular pharmacology and physiology of ghrelin receptor functional selectivity. The research examines two clinically relevant principles of G protein-coupled receptor (GPCR) pharmacology: functional selectivity (the asymmetric engagement of intracellular transducers such as G...
- The National Institute of General Medical Sciences awarded Thomas Jefferson University $392,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on autophagy of mitochondria containing mitochondrial DNA (AUMID). The project investigates the molecular mechanisms that regulate and drive selective autophagy of mitochondria enriched for mtDNA in a cell-type-specific manner, distinct from damage-induced mitophagy. The research will...
- The National Institute of General Medical Sciences awarded The Pennsylvania State University $425,667 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of chromatin remodeling and histone deacetylation. The recipient's research program examines ATP-dependent chromatin remodelers, specifically CHD and ISWI ATPases, and sirtuins, NAD-dependent histone deacetylases, two enzyme families that dynamically regulate...
- The National Institute of General Medical Sciences awarded the University of Pennsylvania $924,095 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate molecular mechanisms controlling actin cytoskeleton dynamics. The research addresses four major knowledge gaps: the ARP2/3 complex's role in actin filament branching and regulation by nucleotide state and binding proteins; filament dynamics at barbed and pointed ends, including cooperative...
The National Institute of General Medical Sciences awarded Pennsylvania State University operating as Penn State Milton S. Hershey Medical Center $410,773 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mitochondria-lysosome crosstalk in health and disease. The research addresses how direct inter-communication between mitochondria and lysosomes affects cellular function and disease. The project examines how membrane contact sites between these organelles stimulate lysosomal function, regulate metabolism, and contribute to age-related pathology through cellular senescence modulation. Work is performed in Hershey, Pennsylvania, with a period of performance through April 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $410.8k | 8/14/26 |