Project Grant R35GM163921
- Federal Project Grant Award Summary The University of Michigan received a $2.01 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2025, with completion targeted for August 31, 2029. This four-year research initiative focuses on enzyme-inspired multimetallic cooperativity and the design of synthetic model systems that investigate how metal ion identity and pairing...
- Federal Grant Award Summary Michigan State University received a $413,244 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 1, 2026, with completion targeted for May 31, 2031. The research focuses on developing catalyst-controlled methylene insertion reactions to streamline pharmaceutical synthesis. Specifically, the project aims to design iron-based catalytic systems that...
- Federal Grant Award Summary Michigan State University received a $335,924 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through March 31, 2031. The award funds research to engineer glycyl radical enzyme (GRE) hydroalkylases for synthetic pharmaceutical applications. The project will develop biocatalytic methods to form new carbon-carbon bonds from simple starting...
- Federal Project Grant Award Summary Michigan State University received an $809,743 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective August 10, 2025, with completion targeted for July 31, 2030. The project focuses on developing novel synthetic methodologies to produce homogeneous proteoglycan-like glycopeptides and glycoproteins bearing defined glycan structures. Recognizing that...
- Federal Project Grant Award Summary Michigan Technological University received a $383,801 Project Grant award dated May 1, 2026, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to advance low-cost synthetic biosensor arrays for rapid multiplex biomarker detection. The five-year research initiative, concluding February 28, 2031, aims to develop cost-effective, scalable, and multiplexed biosensing platforms...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Michigan a Project Grant totaling $429,000 under the Biomedical Research and Research Training program (CFDA 93.859) on March 5, 2026, with completion scheduled for December 31, 2030. The research project investigates the mechanisms by which mammalian cells sense, respond to, and regulate inorganic phosphate (Pi) homeostasis in response to fluctuating extracellular phosphate levels....
- Federal Grant Award Summary Michigan State University received a $294,266 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2026 through May 31, 2030. The award supports the development of mathematical and computational models to reconstruct high-resolution three-dimensional (3D) spatial genome architectures across diverse biological contexts, including different cell types,...
- Federal Grant Award Summary Michigan State University's Henry Ford Health+Michigan State University Health Sciences partnership received a $2.86 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on August 15, 2025, with a completion date of July 31, 2029. This research project aims to model the effects of cadmium exposure on Alzheimer's disease (AD) pathology and neurodegeneration through a multi-principal investigator approach...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the Regents of the University of Michigan a $565,993 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective June 1, 2026, with completion targeted for February 28, 2031. This award supports the development of next-generation native ion mobility-mass spectrometry (NIM-MS) methods for the structural characterization of biotherapeutics, including monoclonal...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the Regents of the University of Michigan a $1.77 million Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective July 1, 2026, through June 30, 2030. This four-year investigation will deliver research outputs focused on elucidating the molecular mechanisms of membrane traffic at endosomes and the trans-Golgi network (TGN), with particular emphasis on...
Michigan State University (operating as Henry Ford Health + Michigan State University Health Sciences) received a $471,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 1, 2026, with completion targeted for April 30, 2031. The research project, "Mechanisms of Metal Receptors Controlling Inorganic Phenotypes," will deliver fundamental scientific discoveries regarding how metalloregulatory proteins control cellular metal ion homeostasis and gene expression. The principal investigator's laboratory will produce mechanistic and structural characterizations of metal receptors that regulate zinc, copper, and mercury sensing, including novel protein-RNA interactions that control zinc regulon switching and DNA topology changes within RNA polymerase promoter complexes. The award will also generate new metal ion sensor technologies developed from insights into metalloregulatory switching mechanisms and quantitative metallomic methods designed to advance understanding of how inorganic phenotypes vary across cells in commensal and pathophysiological interactions with the human host. These research outputs address a critical gap in biomedical knowledge regarding the fundamental principles and macromolecular mechanisms that manage metal ion concentrations essential for optimal cellular health, with implications for understanding metal physiology's role in human disease states.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/15/26 | ||
| Not listed | $471.0k | 7/10/26 |