Project Grant R35GM162332
- Federal Project Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded February 13, 2026, with a completion date of January 31, 2031. This Maximizing Investigators' Research Award (MIRA) supports fundamental biomedical research investigating the mechanisms of translational response to cellular stress,...
- Federal Grant Award Summary The University of Connecticut Health Center received a $457,875 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through July 31, 2030. The grant supports the development of computational methods and tools designed to enhance the application of Nuclear Magnetic Resonance (NMR) spectroscopy in biomedical research. Deliverables include...
- Federal Project Grant Award Summary The University of Connecticut has been awarded $427,604 under the Allergy and Infectious Diseases Research program (CFDA 93.855) by the National Institute of Allergy and Infectious Diseases (NIAID) to conduct fundamental research on the molecular mechanisms underlying conoid extrusion in Toxoplasma gondii. The research, performed at the Storrs, Connecticut campus from August 19, 2025 through July 31, 2027, involves reconstituting core apical complex components...
- Federal Project Grant Award Summary The University of New Mexico Health Sciences Center received a $640,500 Project Grant award effective September 30, 2025, through September 29, 2027, under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications (PTMs). The research...
- Federal Project Grant Award Summary The University of Michigan received a $373,280 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 7, 2025, with completion targeted for January 31, 2027. This research initiative investigates the mechanisms by which cells select and modify specific microtubules through post-translational modifications (PTMs) of tubulin protein, with particular...
- Federal Grant Award Summary The University of Connecticut received a $438,079 Project Grant awarded August 1, 2025, through the National Science Foundation's Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074). The award supports collaborative research investigating fungal cell wall damage response mechanisms in the model organism Aspergillus nidulans through August 31, 2028. The research employs advanced microscopy, genetic manipulation tools,...
- Federal Grant Award Summary The National Institute of General Medical Sciences awarded The Washington University a $427,625 Project Grant effective August 1, 2025, through July 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports fundamental research investigating the molecular mechanisms underlying compound microtubule structure and function within the mammalian centrosome-cilium complex. The research employs advanced methodologies including...
- Federal Project Grant Summary The Trustees of Tufts College received a $249,000 Project Grant awarded September 15, 2025, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The research project, titled "Elucidating the Epigenetic Regulation of Extracellular Matrix and Virus-Induced Fibroblast Activation," will be conducted in Philadelphia, PA, with a completion date of September 14, 2028. The...
- Federal Grant Award Summary The University of California, San Diego received a $125,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through July 31, 2027. This award funds fundamental research investigating the mechanisms of microtubule (MT) regulation at the cellular cortex, with particular focus on how phase separation-dependent condensation of proteins...
- Federal Project Grant Award Summary Yale University received a $669,737 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2027. The grant funds investigator-initiated research focused on elucidating the fundamental mechanisms underlying convective cell motion in biological tissues. The project seeks to identify how tissue-scale surface tensions...
The University of Connecticut Health Center received a $457,875 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective February 15, 2026 through January 31, 2031. This five-year research initiative focuses on investigating the molecular mechanisms of cell migration through the development and application of optogenetic tools that enable precise manipulation of microtubule modifications in living cells. Specifically, the research will employ newly developed light-inducible molecular actuators—OptoTAT and OptoVASH—to selectively and reversibly induce microtubule acetylation and detyrosination, addressing a significant gap in the field caused by the previous lack of tools for acute manipulation of these modifications. The project will generate fundamental scientific knowledge regarding how post-translational modifications of tubulin affect cell migration, cytoskeletal dynamics, and related cellular processes. This research has direct implications for understanding dysregulated cell migration associated with fibrosis and metastatic cancer, ultimately supporting advances in disease diagnosis and treatment. The research will be conducted at the University of Connecticut Health Center's facility in Farmington, Connecticut, leveraging the institution's established capabilities in receiving federal biomedical research funding and collaborative partnerships with other major research institutions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.9k | 2/12/26 |