Project Grant R35GM158031
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to expand the capabilities and streamline the workflow of nuclear magnetic resonance (NMR) spectroscopy for biological research. The $489,500 award, granted on August 1, 2025, supports the development of new methods to extend the size limits of observable systems, improve sensitivity through advanced noise reduction, and...
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $423,330 project grant to the University of Kansas Center for Research Inc. The grant, effective August 1, 2025 through June 30, 2030, focuses on developing innovative technologies to enable new discoveries in biomedical research using mass spectrometry. The key products to be delivered include: A completely noninvasive, non-painful sampling method...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This Project Grant award of $299,985 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), was provided to Doty Scientific Inc. to develop an HR-MAS H/F/X/Y UHF NMR probe for allosteric drug research at physiological conditions. The goal is to create an advanced NMR probe capable of acquiring high-resolution spectra from inhomogeneous samples, such as proteins in a lipid environment, at near-physiological...
- This $316,825 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The research project will develop an innovative intact mass deconvolution method to significantly improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight determination using MS. The key objectives are to implement...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded $1,979,999 to The New York Structural Biology Center, Inc. (NYSBC) on July 15, 2025. The funding will be used to acquire a Bruker BioSpin Fast Shuttle System (FSS) apparatus to be installed on an existing 700 MHz nuclear magnetic resonance (NMR) spectrometer at NYSBC. The FSS apparatus is a technological breakthrough that enables...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $205,002 to San Jose State University Research Foundation to acquire a benchtop nuclear magnetic resonance (NMR) spectrometer. The instrument will enhance the university's educational programs and research initiatives focused on the synthesis and development of new biologically-active small molecules. Specifically, the award...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $457,875 Project Grant to the University of Connecticut Health Center (UCHC) to develop computational methods and tools that enhance the application of Nuclear Magnetic Resonance (NMR) in biomedical research. The project aims to improve the sensitivity, resolution, and reproducibility of NMR workflows, and facilitate easier data sharing and analysis, with a focus on investigating biomolecular dynamics and the quantitative analysis of small molecule mixtures. The award period runs from Sep 1, 2025 to Jul 31, 2030 and leverages UCHC's expertise in biomedical research and the open NMR data and computational platforms, BMRB and NMRBox, to advance the use of NMR technology in fields such as drug discovery, metabolomics, and biomarker identification.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.9k | 8/12/25 |