Project Grant R01GM153862
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- The federal Project Grant award of $248,967.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Massachusetts aimed at understanding mechanisms that control peroxisomal turnover and how peroxisome dysfunction signals to other cellular organelles. The project, awarded on July 10, 2025, with a completion date of June 30, 2028, will leverage recent findings on the role...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research on the mechanisms of mitophagy, a form of mitochondrial quality control, and its role in promoting tissue health and homeostasis. The $373,129 award to Wayne State University will be used to generate genetic tools to manipulate different forms of mitophagy in the fruit fly model organism Drosophila melanogaster. The research...
- This federal Project Grant award, titled "DECODING MITOCHONDRIAL AAA PROTEASE SPECIFICITY", was provided by the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) for $382,931 on September 1, 2025. The award supports fundamental scientific research and advanced training across diverse areas of biomedical science, with a focus on understanding biological processes and developing foundational knowledge for disease diagnosis,...
- This $440,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the ubiquitin and autophagy pathways, which are essential cellular processes involved in proteostasis or protein homeostasis. The research team at the Sloan-Kettering Institute for Cancer Research aims to uncover novel regulatory mechanisms within the ubiquitin system and enhance...
- This federal Project Grant award of $237,874 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the upstream regulation of mitochondrial bioenergetics by the mitochondrial acyl carrier protein (MTACP). The research aims to uncover how MTACP, which sits at the intersection of nutrient inputs and energy expenditure in mitochondria, is regulated through the 4'-phosphopantetheine...
- This federal Project Grant award of $416,240 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the award is to support the University of Maryland, Baltimore's "Training Program in Cellular and Molecular Membrane Biology." The program provides interdisciplinary research training at the molecular, cellular, and systems biology interface, with a focus on understanding the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $407,562 to the University of Denver to conduct research on the molecular mechanisms of lysosome remodeling in response to cellular stress. The 5-year project, starting September 1, 2025, aims to characterize the degradation pathways of vacuole membrane proteins and investigate the transcriptional regulation of...
- This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
- This Project Grant award, totaling $478,269.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to characterize the molecular mechanisms governing plasma membrane stabilization and repair in plants. The University of Maryland, College Park, the award recipient, will conduct this research with the long-term goal of understanding how plant cells autonomously repair damage to their...
This federal Project Grant award of $686,324, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports mechanistic studies on the role of the E3 ubiquitin ligase MARCH5 in regulating mitochondrial and peroxisomal function. The grant recipient, the University of Maryland, Baltimore, will investigate how MARCH5 activity is vital for peroxisome biogenesis and how it protects mitochondria from the toxic effects of abnormal peroxisomal protein accumulation. This research aims to provide critical insights into the regulation and function of mitochondrial and peroxisomal quality control and biogenesis pathways, with potential implications for developing new therapies for diseases linked to mitochondrial and peroxisomal dysfunction. The project period is from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.3k | 8/27/25 |