Project Grant R35GM162139
- Federal Grant Award Summary The University of Missouri System received a $425,974 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion targeted for December 31, 2030. This research initiative focuses on identifying and characterizing biosynthetic enzymes and metabolic pathways involved in plant-derived steroidal compound production, specifically...
- Federal Grant Award Summary The University of Missouri System received a $357,666 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded July 1, 2025, with completion targeted for May 31, 2030. This five-year research initiative will advance understanding of DNA-manipulating enzyme dynamics through the development and application of single-molecule biophysical measurement techniques, including...
- Federal Grant Award Summary The University of Missouri System received a $411,454 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025 through May 31, 2030. This award supports fundamental research focused on controlling drug crystallization, polymorphism, and physicochemical properties using mechanochemistry techniques. The research program investigates the relationship between...
- Federal Grant Award Summary The University of Missouri System received a $384,896 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for the period July 1, 2025, through April 30, 2030. The award supports research on maximizing peptide therapeutic delivery through biomodulatory materials design. The research will engineer biomaterials with physicochemical properties designed to directly...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Missouri System a Project Grant totaling $386,617 under the Biomedical Research and Research Training program (CFDA 93.859) effective September 1, 2025 through June 30, 2030. The Handa Lab will develop innovative catalytic technologies designed to advance pharmaceutical synthesis by creating safer, more efficient, and cost-effective chemical methods. The research encompasses...
- Federal Project Grant Award Summary The Washington University received a $416,050 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 5, 2025, with an ultimate completion date of May 31, 2030. The award supports fundamental basic research investigating metabolic and regulatory control mechanisms governing antibiotic production in filamentous actinobacteria. The research...
- Federal Grant Award Summary The University of Missouri System received a $418,043 Project Grant from the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded August 1, 2025, with completion targeted for July 31, 2027. This award supports the design and development of a self-tunable messenger RNA (mRNA) gene circuit engineered to achieve sustained, precise control...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University in St. Louis a $326,550 Project Grant effective September 1, 2025, through August 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports the development of advanced ecological theory and computational tools to improve understanding and prediction of microbial ecosystem function and dynamics. The research addresses a...
- Federal Project Grant Award Summary The University of Missouri System received a $413,118 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This five-year award supports fundamental research investigating organelle transport and organization mechanisms in mammalian oogenesis, with specific focus on how primary oocytes are determined during...
- Grant Award Summary Brandeis University received a $393,149 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through March 31, 2030. The award funds fundamental research into the regulation of PPM (protein phosphatase methylesterase) family serine/threonine phosphatases, with the objective of advancing understanding of how protein phosphatases are regulated and directed...
Grant Award Summary The University of Missouri System received a $427,526 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective April 1, 2026, through January 31, 2031. The award supports fundamental research investigating the functions and mechanisms of bacterial serine-threonine (S/T) and serine-threonine-tyrosine (S/T/Y) kinases, with particular focus on post-translational protein modifications in bacterial cellular signaling. The research examines how bacteria employ these signaling systems to adapt to environmental changes, maintain homeostasis under stress conditions, and develop resistance to antibiotics and host immune responses. The research deliverables will advance understanding of highly conserved HANKS-type eukaryotic-like penicillin-binding and serine-threonine associated (PASTA) kinases found in gram-positive bacteria, which regulate critical physiological processes including carbon metabolism, cell signaling, peptidoglycan biosynthesis, virulence, and biofilm formation. By elucidating the molecular mechanisms underlying bacterial stress responses and signaling pathway coordination, the project is designed to provide foundational knowledge essential for developing novel antimicrobial therapeutics and understanding bacterial contributions to human health and disease. The research will be conducted at the University of Missouri System's Columbia, Missouri facility.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.5k | 3/18/26 |