Project Grant R35GM161809
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded The Johns Hopkins University $420,936 for a Project Grant (CFDA 93.859, Biomedical Research and Research Training) on April 1, 2026. The award funds research investigating mechanisms of protein self-assembly coupled to membrane mechanics in clathrin-mediated endocytosis. The research addresses how cargo controls the nucleation and growth of...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $406,026 on March 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of biomolecular condensate dynamics. The work addresses the need for quantitative mathematical models to interpret experimental measurements of biomolecular condensates—non-membrane-bound organelles formed through phase separation that enable cellular functions including ribosomal...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $426,250 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to probe translation regulation by imaging single protein-mRNA interactions in live cells. The research project establishes systems to visualize single protein-RNA interactions in live cells and refines single-molecule translation assays to correlate protein binding with translation dynamics. The work...
- The National Institute of General Medical Sciences, part of the National Institutes of Health, awarded $345,581 to the University of Pennsylvania on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to visualize and characterize how bacteria and archaea use DNA-bending proteins to fold genomic DNA into three-dimensional shapes that regulate CRISPR-associated integrase function during adaptive immunity to phage infection. The project will employ...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $326,463 on June 8, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate live-cell functions of histone post-translational modification readers and the histone H2A.Z variant in epigenetic regulation of transcription. The research uses live-cell single-molecule imaging and genomic approaches in budding yeast to elucidate how histone PTM readers and H2A.Z dynamically...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $334,325 for a Project Grant (R01GM164381) on July 1, 2026, to elucidate the structural and biochemical basis of histone H2A.Z exchange by the human SRCAP chromatin remodeling complex. The research addresses substrate specificity, regulation by histone modifications, and interplay with the TIP60 histone acetyltransferase complex to define molecular mechanisms governing H2A.Z dynamics and their impact on...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $2,001,691 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop PURGE, a computational toolkit for prioritizing guide RNAs in CRISPR epigenome editing applications. The research addresses a fundamental limitation in CRISPR-based epigenome editing: only 10–20 percent of guide RNAs targeting distal regulatory elements successfully...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Johns Hopkins University a $2.14 million Project Grant (CFDA 93.859: Biomedical Research and Research Training) effective September 1, 2025 through August 31, 2029 to conduct fundamental research on the molecular mechanisms of ribosome-mediated kinase signaling. The research project will investigate how ribosomes directly sense cellular stress and initiate downstream signaling pathways,...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $412,124 in Project Grant R35GM162386 on March 18, 2026, to support mechanobiological research into collective cell movement across in vivo and in vitro models. The research integrates biology and engineering to decode mechanical principles governing collective cell behaviors during tissue morphogenesis and to engineer synthetic cues that recreate these behaviors by design in cultured systems. The work...
- The National Institute of General Medical Sciences awarded The Johns Hopkins University $458,950 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research deciphering signaling network dynamics, structure, and function. The research investigates how cells detect and respond to environmental cues and intercellular signals through complex, dynamic signaling networks. The work pursues two complementary directions: developing high-throughput...
The National Institute of General Medical Sciences awarded The Johns Hopkins University $388,750 on August 5, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of CRISPR immunity and DNA methylation through Project Grant R35GM161809. The funded work spans two research areas. The first investigates how prokaryotes acquire resistance to viruses and plasmids by integrating foreign DNA into CRISPR clusters, with the goal of understanding the molecular mechanisms governing CRISPR-mediated resistance in prokaryotes. The research will employ cryo-EM and biochemical, biophysical, and cell-based approaches to study how CRISPR-associated proteins use guide RNAs to destroy foreign nucleic acids. The second area examines UHRF1, an epigenetic regulator of DNA methylation that maintains genome stability. The work will use cryo-EM to determine structures of UHRF1 in complex with its nucleosome substrates, addressing the poorly understood structural basis of UHRF1 interactions with methylated nucleosomes. Work is performed in Baltimore, Maryland. The period of performance runs from August 5, 2026 through April 30, 2031. The assistance type is Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $388.8k | 8/5/26 |