Project Grant R35GM161749
- This $385,191 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to study the structure, function, and regulation of ATP-sensitive potassium (KATP) channels. The project aims to develop novel spectroscopic tools to simultaneously probe KATP channel structure and function, with the goal of understanding how ligand binding and long-range communication between subunits in the...
- Federal Grant Award Summary This $249,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports investigator-initiated research on potassium (K+) channel structural dynamics. The award, issued March 1, 2026, with a completion date of February 28, 2029, funds research being conducted at Texas Tech University Health Sciences Center in St. Louis, Missouri. The research will employ...
- This $644,900 Project Grant, awarded July 1, 2025, through the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on PAS (Period-Arnt-Singleminded) domain proteins and their signaling mechanisms. The award, administered by the Research Foundation of the City University of New York's Advanced Science Research Center and scheduled for completion by June 30, 2030, will deliver structural, biophysical,...
- This federal Project Grant award of $525,436.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the structural pharmacology of GIRK channel disease mutants. The research aims to elucidate the molecular mechanisms underlying the loss of potassium selectivity and constitutive activation of GIRK2 channels associated with Keppen-Lubinsky syndrome, a...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $394,214 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025, through June 30, 2030. This award supports continuation of research investigating intracellular lipid transfer mechanisms, building upon prior funded work (R01 GM127631). The research centers on characterizing how...
- Federal Project Grant Award Summary The Sloan-Kettering Institute for Cancer Research received a $534,160 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2025, through May 31, 2030. This award supports fundamental research to elucidate the molecular mechanisms of protein function, specifically focusing on proteins and protein complexes involved in intracellular ion...
- Federal Project Grant Award Summary The University of California, San Francisco received a $576,104 Project Grant award from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859) effective August 15, 2025, with completion scheduled for July 31, 2030. The award supports fundamental research to elucidate the molecular and atomic-level mechanisms of integral membrane proteins, with particular emphasis on understanding how...
- This National Science Foundation Project Grant under the Integrative Activities program (CFDA 47.083) provides $193,620 to the University of Delaware from February 1, 2023 to January 31, 2025. The funding will support research using computational and experimental ultrafast vibrational spectroscopy to unravel the gating mechanisms of ion channels. Specifically, the awardee will combine molecular dynamics simulations with computational spectroscopy to study activation mechanisms of potassium...
- This $299,997 National Science Foundation project grant, funded through the Mathematical and Physical Sciences program (CFDA 47.049), will support the development of advanced computational tools to model voltage-dependent ion channels and further mitochondrial research. Specifically, the Medical College of Wisconsin will create state-of-the-art mathematical models, numerical algorithms, and software to study how the electrostatics and kinetics of the voltage-dependent anion channel alter species...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Ohio State University a $433,125 Project Grant on June 23, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports investigator-initiated research focused on elucidating the functional role of calcium-activated small conductance potassium (SK2) channels in astrocytes. The research aims to identify SK2 as a...
This $429,000 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research on the structure and function of ATP-sensitive potassium (KATP) channels at Oregon Health & Science University. The award, effective April 1, 2026 through March 31, 2031, funds investigator-initiated research aimed at understanding the structural mechanisms by which KATP channels—hetero-octameric membrane protein complexes essential for coupling cellular energy metabolism to membrane excitability—interact with physiological and pharmacological ligands across multiple tissue-specific isoforms. The research deliverables include advancing structural characterization of KATP channel variants and their interactions with ligands using cryo-electron microscopy and related structural biology techniques. The ultimate objective is to translate this structural knowledge into mechanism-based, isoform-specific therapeutic interventions for diseases caused by KATP channel dysfunction, including congenital hyperinsulinism, neonatal diabetes, and related endocrine, cardiovascular, muscular, and neuronal disorders. This work builds upon the principal investigator's prior achievements in determining the first high-resolution structures of SUR1/KIR6.2 channels and subsequent ligand-bound conformational states, directly advancing the scientific understanding necessary for precision medicine applications in KATP channel-related pathologies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 3/19/26 |