Project Grant R35GM160124
- This federal Project Grant award of $660,632 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research aimed at understanding the structure and dynamics of the fusion pore, a critical component of the membrane fusion process that underlies neuronal function. The key objectives of the research are to: 1) leverage a novel reconstituted system to...
- This $382,436 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms regulating the synthesis, sorting, trafficking, and release of neuropeptides from dense core vesicles within neurons. The project aims to create new transgenic fly lines to directly visualize these intracellular processes in vivo using advanced microscopy techniques. Key...
- The Federal Grant Award of $669,737.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The award, with a performance period from September 1, 2025 to August 31, 2027, supports a research project focused on investigating the principles underlying convective cell motion and its coordination with cell migration within tissues. The research aims to provide fundamental insights...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $2,102,917 Project Grant to Yale University on September 1, 2025. This grant supports fundamental research on the biological role and pharmacology of EXPERA family proteins, including sigma-2 receptor and TM6SF2, and their effects on sterol homeostasis. The research aims to elucidate the precise biological functions of sigma-2 receptor, an enigmatic...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This $361,283 Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 Biomedical Research and Research Training, supports research at Yale University focused on advancing the fields of molecular structure analysis and molecular dynamics simulations. The research aims to develop novel methods and algorithms that leverage cutting-edge techniques like cryo-electron microscopy and molecular...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $407,562 to the University of Denver to conduct research on the molecular mechanisms of lysosome remodeling in response to cellular stress. The 5-year project, starting September 1, 2025, aims to characterize the degradation pathways of vacuole membrane proteins and investigate the transcriptional regulation of...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,313,209.00 to Yale University to conduct research on the molecular mechanisms governing diverse vesicle release processes. The research aims to elucidate how different vesicle populations form unique SNARE protein configurations, driving varying modes of vesicle fusion and release kinetics. This work will provide new insights into the regulation of critical physiological functions, such as neurotransmission, hormone secretion, and metabolic homeostasis, while also investigating linkages between vesicle fusion disruptions and neurological, endocrine, and other disorders. The project will leverage advanced imaging technologies and cellular assays to explore vesicle heterogeneity, synchronous and asynchronous exocytosis, and fusion pore dynamics. The award period is from September 8, 2025 to September 7, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 9/8/25 |