Project Grant R01DK144192
Award Date 8/20/25
Completion Date 6/30/29
Dollars Obligated $631K
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
- This Project Grant award, with $1,331,148 in funding from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the mechanisms of islet cell compensation for beta-cell mass deficiency in type 2 diabetes. The research aims to determine the signaling pathways through which increased glucagon secretion from pancreatic alpha-cells helps preserve...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $153,266 in funding from March 1, 2025 through December 31, 2029. The grant supports a research career development program for the Principal Investigator, Dr. Samantha Adamson, to investigate the role of calcium-mediated paracrine signaling in pancreatic islet cell cilia and its relevance...
- The federal Project Grant award of $2,107,630 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a longitudinal study to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to utilize PET and MRI techniques to provide a comprehensive picture of beta...
- The University of California, Davis received a $126,480 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to conduct research on the role of the signaling protein 14-3-3-z in regulating the crosstalk between pancreatic islet cells. The research aims to define a new pathway regulating 14-3-3-z expression in beta cells and investigate how this impacts alpha cell function and glucose-stimulated insulin secretion. This project is expected...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $705,817 in funding to the University of California, Irvine to conduct research on the differential role of cyclic adenosine monophosphate (cAMP) signaling in pancreatic beta cells. The research aims to investigate how cAMP signaling originating from different intracellular compartments, such as the cell surface...
- This federal Project Grant award of $2,325,005 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research at Mayo Clinic to investigate the molecular mechanisms underlying the imbalance between autophagy and extracellular vesicle secretion pathways in pancreatic beta cells under diabetogenic stress conditions. The research aims to improve understanding of type 2 diabetes pathogenesis...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $153,554 Project Grant to the Beckman Research Institute of the City of Hope. This grant, awarded on September 15, 2025, supports research aimed at unveiling novel targets for type 1 diabetes therapy by investigating the functional heterogeneity of pancreatic alpha cells and their interactions with beta and delta...
- This $2,782,476 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to determine the molecular mechanisms underlying pancreatic beta cell response to metabolic stress, a key factor in the development of type 2 diabetes. The 4-year project aims to leverage in vitro human beta cell models, single-cell transcriptomic analyses, and targeted drug screening to delineate the dynamic chromatin and transcriptomic changes that...
- This $146,829 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the molecular mechanisms by which the bacterial protein BEFA (beta-cell expansion factor A) induces the proliferation and metabolic maturation of pancreatic beta cells. The research, conducted at the University of Oregon, utilizes single-cell imaging, genetic...
- This Project Grant award of $223,176 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a research project titled "The Contribution of Mitochondrial DNA Damage to Diabetes-Related Beta-Cell Failure". The award, which runs from December 27, 2024 to August 31, 2026, provides funding for Dr. Rebecca Davidson, a postdoctoral research fellow at the University of Michigan, to...