Project Grant R35GM161300
- Federal Project Grant Award Summary The University of Arizona received a $379,394 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) effective July 1, 2025, through June 30, 2030. The award supports fundamental biomedical research investigating the mechanisms of differential protein activation in hydrogen peroxide (H2O2)-mediated cellular stress responses. The research will employ fluorescent...
- Federal Project Grant Award Summary Arizona State University received a $413,036 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2027. The award supports the development of a novel single-molecule glycosaminoglycan (GAG) sequencing method using fluorophore-labeled lysosomal enzymes. Glycosaminoglycans are large, linear, sulfated...
- Federal Project Grant Award Summary The University of Arizona received a $376,481 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2026, through March 31, 2031. This award supports fundamental research to develop bioinspired design principles for clearance-resistant and stress-responsive therapeutic microcarriers. The project addresses a critical limitation in current...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded the University of Arizona a $1.39M Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) effective June 1, 2026, through May 31, 2030. This research initiative will deliver fundamental scientific research aimed at identifying and modulating cellular pathways that govern quiescence deepening and transition to senescence—two distinct dormancy states critical to tissue...
- Federal Grant Award Summary The University of Arizona received a $659,591 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025, through June 30, 2030. This award funds fundamental biomedical research investigating the Target of Rapamycin kinase Complex I (TORC1) signaling network in yeast (Saccharomyces cerevisiae). The research aims to elucidate how TORC1 functions at...
- Federal Grant Award Summary The University of New Mexico Health Sciences Center received a $419,375 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded April 1, 2026, with completion targeted for January 31, 2031. The project, titled "Systemic Effects of Metabolic Enzyme Dysfunctions," delivers fundamental biomedical research investigating how dysfunctions in...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $440,000 through its Biomedical Research and Research Training program (CFDA 93.859) to the Sloan-Kettering Institute for Cancer Research, effective August 1, 2025, with completion targeted for May 31, 2030. This Project Grant supports fundamental research investigating the mechanisms of lipid droplet (LD) protein targeting—a critical area of cell biology with direct implications for...
- Federal Grant Award Summary The University of Arkansas received a $562,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2028. This award supports fundamental research investigating lysine aminoacylation, an emerging protein post-translational modification observed in human metabolic enzymes. The research project will advance understanding...
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $2.01 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award funds fundamental biomedical research investigating the effects of pathological conditions on the AKT protein kinase within the phosphoinositide 3-kinase (PI3K)-AKT signaling...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded $1,792,800 to The University of Texas Southwestern Medical Center on September 10, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop the AKG-ON biosensor system. This project, which runs through August 31, 2029, addresses a critical gap in biomedical research tools by creating a nuclear alpha-ketoglutarate (AKG) measurement system capable of...
The National Institute of General Medical Sciences (NIGMS) awarded the University of Arizona a Project Grant totaling $407,323 under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research on glyoxalase 2 (GLO2) as a therapeutic target for disease treatment. The five-year award, effective June 1, 2026 through May 31, 2031, funds investigator-initiated research aimed at understanding how protein post-translational modifications (PTMs) regulate cellular metabolic sensing and homeostasis. The research will employ advanced liquid chromatography-mass spectrometry (LC-MS/MS) methods to identify and quantify global changes in PTMs, with specific focus on characterizing the substrate profile for GLO2, determining how acylglutathione intermediates control lysine acylations, and establishing the regulatory mechanisms governing these modifications in cellular systems. This project contributes to NIGMS's mission of supporting basic research that advances understanding of biological processes and establishes foundations for disease diagnosis and treatment. The research has direct applications to several disease areas including sepsis, autoimmunity, cancer, and diabetes, where perturbations in metabolic sensing mechanisms play a critical role in disease pathogenesis. The award represents continuation of previous successful funding and reflects the investigator's demonstrated capability in PTM biology research and methodology development.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $407.3k | 5/18/26 |