Project Grant R35GM160499
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- This federal Project Grant award of $386,617 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop safer and more efficient chemical methods for the synthesis of complex, fluorinated, and highly functional pharmaceutical compounds. The key research areas encompass: (1) electromicellar catalysis for the formation of fluorinated heterocycles, allenes, and reactive intermediates; (2) enantioselective...
- This Project Grant award of $249,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is to support research at Duke University to expand the capabilities of enzymes beyond their natural functions for synthesizing medicinally important chemical compounds. The key products or services to be delivered include engineering heme enzymes and methionine sulfoxide reductases to catalyze aminations and oxidations,...
- This $373,117 Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) supports Emory University's development of novel "bowl-shaped" catalysts for selective C-H functionalization. The research aims to transform pharmaceutical drug synthesis by enabling access to new chiral scaffolds and enhancing site-selectivity in unactivated C-H bond functionalization. Over the 5-year project period from August...
- This federal Project Grant award for $874,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on enantioselective and site-selective C-H activation reactions. The key objectives are to develop next-generation ligands capable of enantio- and site-selective C(SP3)-H activation of aliphatic carboxylic acid substrates, as well as to achieve enantio- and site-selective ring...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $401,233.00 to Duke University to develop new catalytic selective amination methods and aminofunctionalization cascades. The goal is to streamline the creation of structurally complex and richly functionalized novel nitrogen-containing molecules from readily available starting materials, such as alkenes, dienes,...
- This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $357,056.00 to Wayne State University from January 1, 2025 to December 31, 2029. The award will fund efforts to adapt heterogeneous materials and macromolecules for use in high-throughput experimentation approaches to organic synthesis. This includes developing colloidal suspensions of insoluble inorganic reagents, creating...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $552,403 Project Grant to The Trustees of Columbia University in the City of New York. The grant, effective September 1, 2025 through August 31, 2030, will support research to develop innovative methods for the selective synthesis of functionalized amines and heterocycles from common feedstock chemicals. The research aims to address unmet needs in...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $221,448 project grant to the Massachusetts Institute of Technology (MIT) on May 15, 2025. The grant supports the development of peptide catalysts for stereo- and site-selective carbon-carbon bond formation using automated fast-flow peptide synthesis and machine learning. The research aims to leverage MIT's expertise in areas such as molecular...
This $412,632 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the biocatalytic synthesis of complex medicinal small molecules. The award, with a performance period from August 1, 2025 to July 31, 2030, will fund the development of computer-aided synthesis planning (CASP) tools to generalize known enzymatic reactions and predict routes for producing challenging drug molecules. Key focus areas include improving the ability of CASP tools to propose enzymatic routes with minimal expert intervention, enabling the integration of organic and enzymatic steps for more efficient syntheses, and enhancing the selection of appropriate enzymes to catalyze the proposed reactions. This research aims to accelerate drug discovery and production through more automated, scalable biocatalytic approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.6k | 7/25/25 |