Project Grant R35GM160480
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $389,600.00 to Drexel University to conduct research on the physical mechanisms of 3D cell motility. The project aims to investigate how the structure of 3D extracellular matrices affects actomyosin contractility and water influx, which are essential for cell movement through 3D environments like wound healing and...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanobiology of multicellular morphogenesis. The $365,077 award to the University of Arkansas, Fayetteville, aims to measure the distribution of intercellular mechanical forces during morphogenetic processes, such as branch elongation/retraction and bifurcation/budding, and connect these...
- This federal Project Grant award, valued at $428,202.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project to elucidate the systems-level mechanisms that generate robustness in organ size and shape. The principal investigator, based at Cornell University, will leverage advanced live imaging, genetic engineering, image processing, and computational modeling to investigate...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This $414,285 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research into the dynamic pattern formation and self-organizing behaviors of the cell cortex. The research aims to elucidate the principles underlying cortical reorganization processes that drive critical cellular functions like cell division, locomotion, and damage response. The primary awardee is the...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $490,841.00 to Trustees of Dartmouth College to conduct research on the mechanical coordination and mechano-biochemical feedback mechanisms underlying epithelial folding during embryogenesis. The research aims to elucidate the regulatory networks and physical principles that govern how tissues generate, sense, and...
- This federal Project Grant award of $440,454 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Washington University in University City, Missouri. The award will support research on how epithelial cells in mechanically heterogeneous microenvironments, such as those found in the gut, lungs, and skin, sense and respond to both mechanical and biochemical cues in the extracellular matrix. Key...
- This federal Project Grant award of $374,595.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the impact of controlled 3D topographical design on biological interactions. The award aims to: (1) Develop versatile 3D topographic nanopatterning tools that can accurately replicate dynamic 3D topographies found in natural biological systems; and (2) Develop a suite of 3D model systems...
- This Project Grant award of $385,671 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop new 3D printing techniques for creating biomimetic cell culture matrices. The key objectives are to: 1) Investigate the impacts of using visible and near-infrared light versus UV light in digital light processing (DLP) 3D printing on cell viability and metabolism; 2) Determine optimal...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $443,878 to The Trustees of Columbia University in the City of New York to investigate how macroscopic 3D tissue geometries, such as curvature, concavity, continuity, and aspect ratio, influence cell morphology, gene expression, and tissue homeostasis. The research program aims to address three fundamental questions: (1) how tissue geometry affects steady-state cell morphology and transcriptional activity, (2) how cells respond to dynamic changes in tissue geometry, and (3) how cellular signals propagate within tissue in response to changing geometric boundaries. The university will leverage its recently developed edgeless tissue constructs platform to systematically decouple and investigate the effects of specific geometric cues in 3D. The award period runs from August 5, 2025, to June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $443.9k | 8/4/25 |