Project Grant R35GM160467
- This federal Project Grant award, valued at $395,200.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by the University of Southern California (USC) to develop novel computational methods for inferring complex demographic histories and detecting deleterious genetic variation across global human populations. The key products and services to be delivered under this 5-year...
- This federal Project Grant award of $423,750.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on May 1, 2025, supports a research project at New York University (NYU) School of Medicine to develop new conceptual and statistical approaches that integrate molecular, cellular, and population genetics to better understand the genetic basis of complex human traits and diseases....
- The National Institute of General Medical Sciences (NIGMS) awarded a 5-year, $616,786 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, San Francisco (UCSF) to conduct research aimed at uncovering how evolutionary forces shape patterns of genetic variation and drive phenotypic variation across human populations. The research focuses on three key areas: 1) exploring the effects of recessive deleterious alleles...
- This federal Project Grant award of $258,986 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program supports research to unravel the genetic basis of complex trait variation and novel trait evolution. The primary focus is to explore cryptic genetic variations that are revealed through environmental perturbations, and to investigate genomic signatures in natural populations that have adapted to extreme environments....
- This $780,113 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop methods for quantifying and correcting biases in the genetic study of complex traits. Specifically, the research will: Create a comprehensive simulation framework to model realistic intergenerational dynamics and understand genetic transmission across generations. This will help correct biases in current methodologies used to study genetic architecture....
- This Project Grant award of $451,259.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to illuminate the role of chromatin composition and regulation in the repair of double-strand breaks in heterochromatin. The research, conducted by the University of Southern California, aims to: 1) establish the function of "silent" chromatin marks in promoting early heterochromatin repair;...
- The University of California, Los Angeles (UCLA) received a $433,125 Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859) from the National Institute of General Medical Sciences (NIGMS). The goal of this five-year project is to thoroughly and mechanistically characterize the effects of genomic variation on genome function and phenotypes. The project will adopt a multidisciplinary approach that integrates cutting-edge technologies, including...
- This federal Project Grant award of $267,098 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Los Angeles (UCLA) on August 1, 2025. The project, titled "Learning Gene Regulatory Networks under Latent Confounding and Data Dependence," aims to develop statistical methods to infer the structure of gene regulatory networks (GRNs) and identify direct causes of...
- The federal Project Grant award of $420,984.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to develop statistical methods for analyzing deep mutational scanning (DMS) data. The research aims to improve the interpretation of DMS experiments, which can measure how genetic variants affect protein function, in order to better understand the mechanisms underlying basic biology and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $413,300.00 to the University of Southern California (USC) to conduct research in three critical areas of human genetics. The funded research will: Model recessive selection on complex traits by leveraging X chromosome data to better understand the strength of selection across different traits and diseases. Explore gene-environment interactions using innovative statistical models, focusing on how genetic risk evolves with age and environmental exposure. Develop novel methods based on ancestral recombination graphs to refine the understanding of human demographic history, including migration patterns and ancient admixture events. This research aims to generate new insights into genetic variation, improve the predictive accuracy of polygenic risk scores, and clarify population histories, with broad applications across diverse genetic datasets. The award period runs from August 15, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $413.3k | 8/14/25 |