Project Grant R35GM160317
- This Project Grant award of $222,708.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define the mechanisms by which individual microtubules are identified and chosen in cells for specific post-translational modifications. The research aims to determine how cells utilize mechanical cues to drive microtubule modifications and how these cues may be altered to impact cellular...
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
- This $427,625.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research aims to elucidate how specialized triplet and doublet microtubules, formed with the key proteins delta-tubulin and epsilon-tubulin, contribute to the...
- This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by...
- This federal Project Grant award of $195,180.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is for a research project titled "QUANTIFYING THE CONTRIBUTION OF SUPRACELLULAR ACTOMYOSIN NETWORKS DURING MOUSE NEURAL TUBE CLOSURE". The research aims to quantify key features of the actomyosin networks in the mouse neural tube during the closure process, in order to test a proposed "lateral...
- This federal Project Grant award of $374,595.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the impact of controlled 3D topographical design on biological interactions. The award aims to: (1) Develop versatile 3D topographic nanopatterning tools that can accurately replicate dynamic 3D topographies found in natural biological systems; and (2) Develop a suite of 3D model systems...
- This $228,340 federal Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the role of endoplasmic reticulum (ER)-to-actin tethering in cell migration, a critical process for tissue development and repair. The research aims to determine the mechanisms by which the ER interacts with the actin cytoskeleton and spatially coordinates ER-actin...
The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and function. The research plan leverages a novel method to isolate and study myelinated axons in their native form, which will enable investigating the tissue-specific molecular adaptations of these cytoskeletal structures. This research is expected to have broad applications in developing therapeutic strategies, improving tissue engineering, and advancing the understanding of cellular mechanics. The award has a performance period from August 9, 2025 to May 31, 2030 and will be conducted by the Van Andel Research Institute (UEI: QLRCUJ8JTN53) in Michigan.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 8/9/25 |