Project Grant R35GM160280
- The National Institute of General Medical Sciences (NIGMS) awarded a $222,708 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to Yale University to develop peptide-containing transition metal catalysts for site-selective transformations of the antibiotic thiostrepton. This research seeks to enable selective modifications of complex natural product molecules, with the goal of potentially developing new and more potent antibiotics to address the growing challenge of...
- The National Institute of General Medical Sciences (NIGMS) awarded a $377,123 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF SUNY) on September 1, 2025. The grant supports a research program aimed at providing structural and mechanistic insights into the ligand specificity of A1-adrenergic receptors (A1-ARs) through the use of cryo-electron microscopy, biochemical, and cellular studies....
- The National Institute of General Medical Sciences (NIGMS) awarded a $609,493 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Sloan-Kettering Institute for Cancer Research. The grant, awarded on June 1, 2025 with a final completion date of May 31, 2030, supports fundamental scientific research to unravel the molecular mechanisms underlying lipid and energy storage in eukaryotic cells. Key objectives include: 1) elucidating the structure, function,...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,313,209.00 to Yale University to conduct research on the molecular mechanisms governing diverse vesicle release processes. The research aims to elucidate how different vesicle populations form unique SNARE protein configurations, driving varying modes of vesicle fusion and release kinetics. This work will provide new...
- This $213,284 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 (Biomedical Research and Research Training) supports research by Yale University to investigate how the cell membrane environment impacts the structure and function of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that plays a crucial role in cellular processes and cancer development. The key objectives are to: 1) Use kinetic assays and defined...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
- The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $2,102,917 Project Grant to Yale University on September 1, 2025. This grant supports fundamental research on the biological role and pharmacology of EXPERA family proteins, including sigma-2 receptor and TM6SF2, and their effects on sterol homeostasis. The research aims to elucidate the precise biological functions of sigma-2 receptor, an enigmatic membrane protein implicated in cancer, Alzheimer's, and neuropathic pain, as well as to discover ligands that can modulate its activity. It also seeks to understand the role of TM6SF2, another EXPERA family member, in lipid metabolism and its association with metabolic dysfunction-associated steatotic liver disease. This work is expected to be completed by August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 8/11/25 |