Project Grant R35GM159997
- The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $508,750 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The grant, awarded on August 1, 2025, supports research to elucidate the chromatin structure and function of double minute chromosomes (DMs) throughout the cell cycle. The project aims to develop novel biochemical and chemical strategies to investigate DM chromatin structure,...
- This federal Project Grant award of $667,480.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to St. Jude Children's Research Hospital Inc. The award supports fundamental scientific research and advanced training focused on understanding the regulation of genome expression by chromatin and how mutations in chromatin proteins contribute to oncogenesis. The research aims to provide new insights...
- The National Institute of General Medical Sciences (NIGMS) awarded a $462,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to St. Jude Children's Research Hospital Inc. in Memphis, TN. The grant will support a 5-year research project to decipher the genetic regulation of bacterial heterogeneity in response to antibiotic stress using single-cell transcriptomics. The research aims to comprehensively characterize bacterial heterogeneity and identify genetic regulators...
- This federal Project Grant award of $508,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at St. Jude Children's Research Hospital Inc. to uncover the epigenetic mechanisms that underlie stem cell fates during embryogenesis. The research focuses on understanding how histone H3 lysine 27 (H3K27) modifiers respond to intrinsic and external cues to dynamically change H3K27...
- The National Institute of General Medical Sciences (NIGMS) awarded a $222,708 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to Yale University to develop peptide-containing transition metal catalysts for site-selective transformations of the antibiotic thiostrepton. This research seeks to enable selective modifications of complex natural product molecules, with the goal of potentially developing new and more potent antibiotics to address the growing challenge of...
- This federal Project Grant award of $524,400.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research at the Scripps Research Institute in La Jolla, CA to develop novel chemical transformations and catalysts that enable the efficient synthesis of structurally complex small molecules for drug discovery. The research aims to address challenges in organic synthesis by...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), has awarded Clemson University a $312,559 project grant for the period of September 1, 2025 to August 31, 2030. The grant supports the development of new deoxygenative functionalization methods to access medicinally valuable chiral amines and fluorinated compounds from alcohols and carboxylic acids. The research aims to enable one-step, stereospecific...
- The National Institute of General Medical Sciences (NIGMS) awarded a $268,538 Project Grant under CFDA 93.859 (Biomedical Research and Research Training program) to the New Hampshire Academy of Science Inc. The grant, titled "LEARNING SCIENCE THROUGH RESEARCH-2", aims to provide pre-college students in rural New Hampshire and Vermont with opportunities to conduct authentic scientific research under the mentorship of professional scientists. The project will develop summer and...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $462,000 Project Grant to the Albert Einstein College of Medicine in Bronx, NY. The grant, awarded on September 1, 2025, with a completion date of August 31, 2030, supports research to establish a new approach for inhibiting protein-protein interactions, a challenging target for conventional small-molecule therapeutics. The research program aims to...
The National Institute of General Medical Sciences (NIGMS) awarded a $2,503,299.00 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to St. Jude Children's Research Hospital Inc. The grant, titled "Developing and Discovering Covalent Inhibitors through Fragmentation-First Experimentation", aims to leverage a novel chemical framework to dramatically simplify access to small molecules and accelerate the processes for studying their interactions with biomacromolecules. The research will unify fragmentation-first experimentation approaches with methods to directly study the reactions of small molecules with proteins and bacterial ribosomes, with the goal of identifying more effective covalent inhibitors. The project period runs from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 8/11/25 |