Project Grant R35GM159993
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is providing $460,625.00 to the University of Massachusetts Medical School (UMASS Medical) to reconstruct gene regulatory networks (GRNs) using population-scale and atlas-scale single-cell datasets. The goal is to overcome challenges in data sparsity and scalability, as well as limitations in existing causal inference methods...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,252,479.00 to the Trustees of Dartmouth College to develop new computational models inspired by evolutionary biology that can detect cellular proliferation, differentiation, and migration from single-cell sequencing data. The goal is to decode the mechanisms of human diseases by reconstructing the history of these...
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
- This $116,105 federal Project Grant award, provided by the National Science Foundation's Division of Mathematical Sciences under CFDA 47.049 Mathematical and Physical Sciences program, supports a collaborative research project between the University of California-San Diego, Xavier University of Louisiana, and the University of California-Irvine. The project aims to develop mathematical models that bridge the evolutionary dynamics of mutant cell growth in the blood between mouse and human...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $1,003,507.00 to the University of Massachusetts Medical School (UMMS) to support their MD-PhD training program. The objective of the program is to train a diverse group of physician-scientists who will conduct innovative and high-impact research to improve individual and population health. Key program elements...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $541,967 to the University of Chicago to investigate the mechanical behaviors of cells and their impact on physiological processes and diseases. The research aims to expand the understanding of adherent cell mechanics and mechanobiology, focusing on the force-sensitive remodeling of cell-cell adhesions and the role of LIM...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 - Biomedical Research and Research Training program, provides $438,629 to the University of Massachusetts to characterize fundamental and conserved mechano-molecular mechanisms of cell division. The research aims to advance understanding of: 1) the functional contributions of extremely large intrinsically disordered regions (ELIDRs) in proteins at the kinetochore and perichromosomal...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under CFDA Program 93.859 Biomedical Research and Research Training, provides $406,250.00 to the University of Massachusetts to develop sophisticated mathematical models, particularly using partial differential equations (PDEs), to investigate the spatial interactions between cells and molecules within tissues. The models aim to capture tissue-specific biochemical and biomechanical characteristics to uncover the pathways and mechanisms that influence various diseases and immune responses, such as in the context of aging, bone deformation, autoimmune diseases like rheumatoid arthritis, and cancer. These models will serve as predictive tools to simulate how different interventions may influence disease progression and immune responses in various tissues. The project period runs from August 15, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.3k | 8/5/25 |