Project Grant R35GM159987
- This federal Project Grant award for $329,039, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to determine the genetic relatedness, effective population size, and local adaptation of invasive Aedes aegypti mosquito populations. The award aims to advance understanding of how evolutionary forces shape the dispersal and population dynamics of this mosquito species, which can transmit...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), is funding research to develop new tools and technologies for vector control of the Aedes aegypti mosquito, an important disease vector. The key focus is on evaluating conditional and sex-specific lethal systems that can restrict lethal transgene expression and reduce the fitness load on mosquito populations, as...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
- The University of California, San Diego (UCSD) was awarded a $500,000 Project Grant from the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences (CFDA 47.074) federal grant program. Through this three-year award beginning June 1, 2023, UCSD will investigate olfactory learning and neuromodulation in the Aedes aegypti mosquito vector. The research aims to elucidate the role of dopamine-mediated plasticity in early olfactory circuits and how...
- This Project Grant award of $611,861 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate chromosomal rearrangements in the Aedes aegypti mosquito. The goal is to characterize the geographic distribution of chromosomal inversions in this mosquito species and determine their association with ecological variables and subspecies differentiation. The research will leverage...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $441,502 to the University of Texas Health Science Center at Houston (UTHealth) to advance CRISPR-based genome editing strategies for managing Aedes aegypti mosquito populations. The key objectives are to: 1) design a CAS12 temperature-dependent system that requires only one strain to produce sterile male...
- This Project Grant award of $2,536,503 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to understand how the ability of Aedes aegypti mosquitoes to tolerate desiccation affects their potential as disease vectors. The research aims to identify genetic mechanisms linking desiccation tolerance to susceptibility to Zika, Chikungunya, and Dengue viruses in the mosquito midgut. Key...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $423,125 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Texas A&M University System Health Science Center. The grant, awarded on July 17, 2025, aims to develop an intein-based QF2 system for controllable protein expression in the nervous system of the Aedes aegypti mosquito. This research seeks to leverage genetic and synthetic biology tools to disrupt the propagation of...
- This $157,884 Project Grant, awarded on December 26, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the effects of a chromosomal inversion in the Anopheles coluzzii mosquito on gene regulation and its relationship to malaria resistance. The central hypothesis is that genetic variation between the inversion forms leads to differential enhancer activity and gene...
- This $198,724 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by the University of California, Santa Cruz on the functional genetic basis of the symbiotic relationship between the Wolbachia bacteria and Drosophila fruit flies. The overarching goal is to develop a robust understanding of the evolutionary genetics and functional mechanisms underlying this host-symbiont...
The National Institute of General Medical Sciences (NIGMS) awarded a $392,299 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to study the genomic basis of rapid and repeated adaptation in the mosquito species Aedes aegypti. The project aims to characterize the genome-wide distribution of adaptive genetic variation and patterns of selection across the mosquito genome, leveraging the species' ability to rapidly adapt to different ecological niches. The project will utilize field studies of allele frequency changes across distinct seasons in Senegal, Africa to further the understanding of how adaptive genetic architecture facilitates rapid evolutionary response to environmental change. The award period runs from September 1, 2025 through August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $392.3k | 8/18/25 |