Project Grant R35GM159972
- The National Institute of General Medical Sciences (NIGMS) awarded a $597,573 Project Grant under CFDA 93.859 - Biomedical Research and Research Training to The Ohio State University (OSU) with a project period from Jun 1, 2025 to Mar 31, 2030. The grant supports fundamental scientific research and advanced training focused on understanding the structure, dynamics, interactions, and function of large protein and protein-nucleic acid complexes that play key roles in human health and disease....
- The Ohio State University was awarded a $988,596 project grant from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences federal grant program (CFDA 47.074). The grant will support research from August 1, 2021 to July 31, 2025 on the structural dynamics and function of proteins using nuclear magnetic resonance spectroscopy and computational methods. The Biological Sciences program aims to advance the field and strengthen the national...
- The Ohio State University received a $932,130 Project Grant award from the National Science Foundation Division of Molecular and Cellular Biosciences under the Biological Sciences (47.074) federal grant program. The University will provide research and education services focused on developing and applying new solid-state nuclear magnetic resonance methods to determine protein structures and interactions in complex biological systems. Specific aims include advancing paramagnetic solid-state NMR...
- The Ohio State University received a $370,871 project grant from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation Engineering program to develop new bioscience tools and methods for measuring nuclear transport capacity. The goal is to gain a comprehensive understanding of the biophysical regulation of large molecule movement into and out of the cell nucleus through nuclear pore complexes. The University will apply biossensor approaches to study...
- This $2,130,924 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research on the regulation of biological oscillators and rhythmic molecular and morphological processes at The Ohio State University. The project aims to advance understanding of the developmental regulation of oscillatory gene expression and protein activity, with a focus on the...
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
- This $427,625.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research aims to elucidate how specialized triplet and doublet microtubules, formed with the key proteins delta-tubulin and epsilon-tubulin, contribute to the...
- This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule...
- The Ohio State University received a $886,192 Project Grant award from the National Science Foundation Division of Civil, Mechanical, and Manufacturing Innovation under the Engineering program (CFDA 47.041) to support research titled "CAREER: A ROLE FOR MECHANICS IN REGULATING CELLULAR CROSSTALK WITHIN INTERVERTEBRAL JOINTS OF THE SPINE" from February 1, 2022 through January 31, 2027. The University, through its Office of Sponsored Programs, will conduct research exploring the role...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
The Ohio State University was awarded a $433,125 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of this 5-year grant is to investigate the molecular consequences and functional implications of microtubule bending in living cells. The researchers will develop innovative molecular tools to precisely manipulate target molecular processes and use techniques like fluorescence microscopy, genetic/pharmacological perturbation, and other molecular tools to comprehensively illuminate the molecular response to microtubule bending, including curvature-induced damage, local microtubule protection, and lateral repair. This fundamental research aims to advance scientific understanding of how cells maintain microtubule integrity and function in the face of mechanical stress, which is relevant to various human diseases linked to microtubule defects.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $433.1k | 7/31/25 |