Project Grant R35GM159612
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award of $416,398 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental scientific research on the regulation of neutral lipid metabolism in eukaryotes. The research program at Texas A&M AgriLife Research, a component of the Texas A&M University System, aims to elucidate the underlying mechanisms controlling the enzymatic activity of acyltransferases...
- The Project Grant award, titled "Simplifying the Description, Not the System: Advanced Ecological Theory for Real-World Microbiomes", is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). Over the 5-year period from September 1, 2025 to August 31, 2030, the $326,550 grant will support research at The Washington University in University City, MO to develop computational tools and statistical...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This federal Project Grant award of $394,214 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the intracellular transfer of lipids between cell membranes. The grant, awarded to Oregon Health & Science University (OHSU), aims to characterize the lipid transport function of two specific proteins, MPP6 and ATP11A, and determine their 3D structures using cryo-electron microscopy. The...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,931.00 to the University of Colorado-Denver to characterize how specialized microbial metabolites mediate interactions within the human microbiome. The research aims to elucidate the role of these metabolites in enabling microbial communities to resist antimicrobial therapies, with the goal of improving...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This $138,459 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to uncover the function and protein subcellular localization of bicistronic loci in the green alga Auxenochlorella protothecoides. The research aims to use gene replacement methods to create mutant strains and compare them to wild-type for phenotyping, including physiological and biochemical...
- This federal Project Grant award of $395,701.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), to the University of Texas at Austin. The funding supports a research program to study the molecular bases of interactions between bacteria and between bacteria and their animal hosts, with a focus on insect microbiomes. The key objectives are to understand: 1) how competitive interactions between...
This federal Project Grant award for $406,652 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to elucidate the fundamental aspects of oleate hydratase (OHYA) biology and its role in lipid-protein interactions across microbial communities. The research will investigate how OHYA acquires unsaturated fatty acid substrates from cell membranes, how bacteria utilize OHYA and distribute hydroxy fatty acids to support colonization and immune modulation, and explore the catalytic mechanisms of OHYA variants. The multidisciplinary approach leverages advanced structural biology, lipidomics, and genetic techniques to provide insights into microbial physiology and protein-membrane interactions, with the potential to inform biotechnological advancements and novel therapeutic strategies targeting microbial lipid metabolism. The award was made to the University of Kentucky Research Foundation on August 7, 2025, with a planned completion date of July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $406.7k | 8/6/25 |