Project Grant R35GM158705
- This $382,616 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the structure, function, and mechanism of bacterial zinc ATP-binding cassette (ABC) transporters. The five-year project, awarded to New Mexico State University, aims to determine the first high-resolution structures of two divergent families of zinc ABC transporters prevalent in human...
- This federal Project Grant award, valued at $440,327.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the grant is to investigate the mechanisms by which gram-negative bacteria, such as E. coli, traffic essential lipoproteins to the outer membrane, a critical barrier that protects these organisms. The research aims to uncover alternative lipoprotein trafficking pathways...
- This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and their physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial...
- This federal Project Grant award of $118,559 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate metalloenzyme-guided discovery of new ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. The key objectives are to: Structurally and functionally characterize copper-bound oxazolin, a natural product from the pathogens Nontypeable Haemophilus...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $506,105.00 to The Medical College of Wisconsin, Inc. to conduct research on the functional dynamics of essential bacterial proteins and develop transformative electron paramagnetic resonance (EPR) spectroscopy technologies. The research aims to gain detailed knowledge of protein structure and dynamics to aid in...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- This federal Project Grant award for $543,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to determine the structural basis by which a C-terminal processing protease activates cell surface signaling for iron import in gram-negative bacteria. The research, to be conducted at North Dakota State University, aims to better understand essential cellular processes in...
- This Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to investigate the molecular mechanism by which the bacterial B-barrel assembly machinery (BAM) complex displays lipoproteins on the cell surface of Gram-negative bacteria. The research aims to identify how the BAM complex recognizes and coordinates the surface exposure of these lipoproteins, which play...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $410,000 in funding to the University of Chicago to conduct research on bacterial secretion systems using cryo-electron tomography. The key objectives are to: Investigate the assembly, disassembly, and function of bacterial flagellar motors (type III secretion systems) and type IV secretion systems, which are involved in...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
This Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program at Northwestern University to study the mechanistic function of ATP-binding cassette (ABC) transporters in pathogenic bacteria. The $498,778 award, effective September 15, 2025, will fund a 5-year research project to investigate how these membrane-bound proteins regulate the uptake of nutrients and other compounds in bacterial cells. The research aims to decipher the molecular mechanisms controlling nutrient transport and how different ABC transporter architectures and selectivity influence bacterial virulence. By combining biochemical, biophysical, and structural biology approaches, the project seeks to advance the fundamental understanding of these essential bacterial systems and their potential as targets for future antimicrobial therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $498.8k | 9/12/25 |