Project Grant R35GM158400
- This federal Project Grant award of $408,750 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Boston University to develop predictive computational methods for simulating redox reactions and charge transfer in proteins. The principal investigator has developed a first-principles protocol for accurately predicting redox potentials and electron transfer rates in proteins, as well as a...
- This federal Project Grant award for $647,301 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of iron-sulfur enzymes. The key objectives are to: Develop synthetic models of iron-sulfur enzyme active sites to characterize their molecular-level structures and reaction mechanisms, and Improve spectroscopic methods for analyzing the complex iron-sulfur clusters...
- This Project Grant award of $223,176 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the structure, function, and mechanism of the carbon monoxide dehydrogenase (CODH) enzyme. Specifically, the award will fund the synthesis and spectroscopic study of biomimetic models of the CODH C-cluster, which is responsible for the enzyme's catalytic activity in carbon dioxide reduction and carbon...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $447,337 to Ball State University to conduct research on the regulator MITONEET and its role in cellular redox homeostasis and signaling. The research aims to investigate how the electronic properties and stability of the MITONEET [2Fe-2S] cluster contribute to the metabolism of sulfur-containing molecules and the...
- This $431,750 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training will support research at Cornell University to enhance the understanding of intercellular communication and its role in coordinating successful tissue regeneration. The project aims to (1) map the cellular and developmental trajectories that lead to different regenerative outcomes, (2) explore the role of intercellular signaling in...
- This Project Grant award, ID R35GM156443, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $419,375 award, spanning January 1, 2025 to November 30, 2029, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to define the functional dynamics of multidomain redox enzymes, with a focus on nitric oxide synthase (NOS) enzymes. The research aims to gain a comprehensive...
- This federal Project Grant award, valued at $428,202.00 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project to elucidate the systems-level mechanisms that generate robustness in organ size and shape. The principal investigator, based at Cornell University, will leverage advanced live imaging, genetic engineering, image processing, and computational modeling to investigate...
- This Project Grant award of $638,334 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to advance the understanding of structural mechanisms underlying protein-small molecule binding and protein function. The project will develop novel computational methods for thermodynamic mapping of proteins, ligands, and surrounding aqueous solvent using molecular dynamics simulations. The goal is to create a...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This $346,582 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support the development of novel statistical and computational methods for genetic epidemiology. The key products and services to be delivered under this 5-year award include: Efficient coalescent-based phylodynamic methods to jointly infer genealogies and model parameters from pathogen genetic data, incorporating...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will provide $380,262 to Cornell University from August 1, 2025 to July 31, 2030 to develop a theoretical framework using path integral quantum mechanics to elucidate the kinetics and mechanisms of redox processes in biological systems. The research aims to address key questions in redox biology, including uncovering the sequence of electron and proton transfer events in enzyme active sites, understanding how the environment affects redox reactivity, and identifying pathways for decoherence and energy dissipation. The project will work with experimental collaborators to build a broadly applicable simulation toolbox and demonstrate the methods on model systems such as a nitrification enzyme, a multi-metal center drug candidate, and a radical relay protein exhibiting long-range electron transfer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $380.3k | 8/1/25 |