This federal Project Grant award of $2,025,831 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports advanced research on the molecular mechanisms of eukaryotic chromosome replication. The grant aims to illuminate both the intrinsic functioning of the eukaryotic DNA replication machinery and its response to various replication stress conditions that can lead to genome instability and diseases like...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000.00 to The Regents of the University of Colorado (University of Colorado-Denver) to conduct research on the molecular mechanisms of DNA replication during mitosis. The research aims to uncover how cells complete replication of the entire genome before cell division, even when replication is not fully finished in the S phase of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $254,919 to the University of California, San Diego (UCSD) over a 5-year period from February 1, 2025 to January 31, 2030. The award supports research to understand the regulatory mechanisms that ensure accurate transmission of the genome during cell division. Key focus areas include investigating how cells prevent incomplete DNA...
This federal Project Grant award for $404,792, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to advance the understanding of telomere biology. The funded project at Yale University aims to yield new mechanistic insights into how telomeres are protected, maintained, and replicated, with potential implications for treating human diseases like cancer and aging. Key focus areas...
The National Institute of General Medical Sciences (NIGMS) awarded a $274,597 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The 5-year grant, effective August 1, 2025, supports research on proteomic and phosphoproteomic remodeling under genomic imbalance, or aneuploidy. The project aims to study the mechanisms of protein regulation and signaling pathways in aneuploid cells, with a focus on distinguishing the effects of chromosome gain...
The National Institute of General Medical Sciences (NIGMS) awarded a $427,571 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The award, which runs from January 15, 2025 to December 31, 2029, will support research to uncover the molecular determinants of cellular identity and the regulation of chromatin states across the cell cycle. Specifically, the...
The National Institute of General Medical Sciences (NIGMS) awarded a $445,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Dana-Farber Cancer Institute, Inc. (Dfci) in Boston, Massachusetts. The grant, which runs from January 22, 2025 to December 31, 2029, supports research to elucidate the molecular mechanisms of DNA double-strand break repair by homologous recombination. The goal of this project is to define the processes that allow cells to...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Federal Grant Program (CFDA 93.859), supports research into the post-transcriptional control of gene expression by the mTORC1 signaling pathway. The $1,675,000 award to Yale University, spanning August 2024 to June 2029, will fund research to understand the molecular mechanisms that regulate mRNA translation and stability in response to nutrient...
The National Institute of General Medical Sciences (NIGMS) awarded a $528,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the Sloan-Kettering Institute for Cancer Research located in New York, NY. The purpose of this 4-year grant, with a period of performance from September 30, 2024 to July 31, 2028, is to develop novel approaches to map the folding and protein occupancy of entire chromosomes with single-nucleosome resolution and single-molecule precision. The...
The National Institute of General Medical Sciences (NIGMS) awarded a $470,000 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The Institute For Cancer Research, a non-profit subsidiary of Temple University, for a 5-year research project starting on September 17, 2024. The goal of the project is to characterize the molecular-level interactions and coordination events coupling the repair of oxidative DNA damage and gene enhancement at G-quadruplex promoter regions in...