Project Grant R35GM158260
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award of $401,253 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate novel cyclic nucleotide signaling pathways and their physiological effects in bacteria. The research program will synthesize chemical tools and use in vitro and in cellulo techniques to investigate the effects of 2',3'-cyclic nucleotide monophosphates (2',3'-cNMPs) on bacterial...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award, valued at $440,327.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The purpose of the grant is to investigate the mechanisms by which gram-negative bacteria, such as E. coli, traffic essential lipoproteins to the outer membrane, a critical barrier that protects these organisms. The research aims to uncover alternative lipoprotein trafficking pathways...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This federal Project Grant award of $2,233,277.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the catalytic mechanisms and regulatory roles of bacterial alarmone hydrolases. The University of Texas Southwestern Medical Center, the awardee, will use structural biology, biochemistry, and bacterial genetics to study how these enzymes, which degrade the signaling molecule...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
- This federal Project Grant award for $543,750.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), will support research to determine the structural basis by which a C-terminal processing protease activates cell surface signaling for iron import in gram-negative bacteria. The research, to be conducted at North Dakota State University, aims to better understand essential cellular processes in...
- The University of Wisconsin - Milwaukee was awarded a $572,553 Project Grant under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to study the evolution of mucoid-based phage resistance in Escherichia coli populations. The objective is to test predictions about the pleiotropic side effects of mucoid-based resistance to a candidate therapeutic phage, with the long-term goal of using phages to steer bacterial populations...
- This federal Project Grant award of $348,963.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental scientific research to investigate the mechanisms of quorum signal synthesis in gram-negative bacteria, with the goal of establishing molecular determinants for substrate recognition and developing quorum sensing inhibitors as potential anti-virulence compounds. The...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $506,105.00 to The Medical College of Wisconsin, Inc. to conduct research on the functional dynamics of essential bacterial proteins and develop transformative electron paramagnetic resonance (EPR) spectroscopy technologies. The research aims to gain detailed knowledge of protein structure and dynamics to aid in the development of effective therapeutics, particularly novel antibiotics to combat drug-resistant bacteria such as Escherichia coli, Salmonella typhimurium, Vibrio cholera, and Enterococcus faecalis. The award period runs from September 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $506.1k | 8/12/25 |