This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) is funding research to investigate the role of mechanical cues in the extracellular matrix in regulating monocyte inflammation. The $406,250 award, which runs from January 1, 2025 to December 31, 2029, will support the development of human stem cell-based culture systems to study monocyte mechanobiology, the investigation of mechanical...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $191,250 to Washington State University (WSU) to conduct research on the immune evasion mechanism of the Lyme disease spirochete, Borrelia burgdorferi. The award supports mechanistic studies on the role of genetic factors in the antigenic variation of the VlsE surface protein, a key mechanism for persistent...
This Project Grant award from the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420) provides $759,974 to Washington State University to develop a novel technique for introducing mutations in the native VlsE gene of Borrelia burgdorferi. The objective is to test several mechanistic concepts of VlsE-mediated immune evasion. This 3-year research project, starting on May 1, 2024 and ending on April 30, 2027, aims to advance the...
This Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the understanding of tissue-resident macrophage biology in vivo. The awardee, The Medical College of Wisconsin, Inc., will utilize a novel small vertebrate model, Danionella cerebrum, to systematically analyze the ontogeny, kinetics, and function of tissue-resident macrophages during homeostasis,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $445,873 to Worcester Polytechnic Institute (WPI) to conduct research on the structure, function, and dynamics of non-canonical stress granules. The research aims to characterize the components of non-canonical stress granules induced by UV radiation, elucidate their relationship to apoptosis, and use them as a model to understand the...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under its Biomedical Research and Research Training program (CFDA 93.859), supports research to understand how cells regulate protein synthesis in response to environmental stressors. The $372,880 award, with a period of performance from May 1, 2025 to April 30, 2030, will fund research by The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. to investigate three...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,483,910 to The Washington University in St. Louis to conduct research on novel genetic mechanisms underlying primary immune regulation disorders. The 5-year project, which commenced on April 8, 2025, aims to investigate three key areas: 1) epigenetic mechanisms leading to autosomal random monoallelic expression in...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $479,249 to Washington University to conduct research on the molecular mechanisms regulating neutrophil proinflammatory activity in sepsis. The research aims to understand how neutrophil A20 signaling contributes to organ damage in sepsis, utilizing biochemical, cell biological, and intravital imaging...
This National Science Foundation Project Grant of $649,998 will fund research into adaptive and regulatory diversity in natural CRISPR-Cas systems from March 1, 2023 to February 29, 2028. The grant was awarded under the Biological Sciences program (CFDA 47.074) to further the program's goals of advancing the biological sciences and strengthening the Nation's scientific enterprise. The University of Washington will investigate the mechanisms by which diverse CRISPR systems acquire immunological...
This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program provides $1,088,500.00 to The Washington University in St. Louis to conduct research on the neural circuits and cytokine codes that govern behavioral responses to inflammation. The project aims to elucidate how the immune and central nervous systems communicate to regulate motivation and mood, with a focus on chronic inflammatory conditions...