Project Grant R15GM157697
Award Date
5/1/25
Completion Date
4/30/28
Dollars Obligated
$446K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01609, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $410,000.00 in funding to The Trustees of Princeton University to develop accurate and efficient simulation models to characterize the molecular structures and interactions within stress granules. Stress granules are cytoplasmic condensates primarily composed of RNA-binding proteins and mRNA, which have been implicated in...
This $381,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research on the cellular mechanisms of lysosomal damage response. The award aims to establish the function of stress granule formation in controlling lysosomal quality, and determine how lysosomal damage induces stress granule formation. The research will be conducted by the University of New Mexico Health Sciences...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms that regulate gene expression in mammalian cells under stress conditions. The research aims to gain a deeper understanding of how stress-induced biomolecular condensates, as well as disruptions to transcription termination, drive the cellular stress response. The total award...
This $372,880 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program supports research to understand how cells regulate protein synthesis in response to environmental stressors. The project aims to investigate three key areas: 1) the coordination of eIF2 translation initiation factor complex formation, 2) the mechanisms by which eIF2 selects or disregards mRNAs for translation during the integrated...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), aims to investigate the regulation of germ granules, an RNA condensate implicated in germ cell totipotency. The $375,430 award, effective from Feb 1, 2025 to Dec 31, 2029, will fund research to establish a framework for understanding the regulation of condensates by RNA helicases and the impact of condensation on RNA...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will establish a high-throughput, generalizable quantitative structural cell biology platform to study the cellular mechanisms regulating secretory granule maturation. The $1,245,000 award, effective from July 1, 2024 to April 30, 2029, will leverage soft X-ray tomography and fluorescence lifetime imaging microscopy to map...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will provide $249,000 to Worcester Polytechnic Institute (WPI) to conduct research on the modulators and physiological functions of RNA tailing in the C. elegans oocyte. The objective is to identify the terminal nucleotidyl transferases and exonucleases that modulate RNA tails, and elucidate the mechanisms by which they regulate...
The National Institute of General Medical Sciences (NIGMS) awarded Vanderbilt University a $396,250 Project Grant under the NIGMS Biomedical Research and Research Training Program (CFDA 93.859) to conduct research on the regulation and function of biomolecular condensates. The 5-year project aims to define the core biochemical principles that underpin the spatial and temporal regulation of biomolecular condensates, using the P granule model condensate in C. elegans embryogenesis. Key goals...
This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate how chaperone proteins mediate proteasomal degradation of substrates. The principal investigator will use a multi-disciplinary approach, including in vitro characterization and cryo-electron microscopy, to study how the HSP70/CHIP/BAG-1 chaperone complex affects the various steps of proteasomal...
This federal Project Grant award of $319,730 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research to investigate the role of Hsp70 phosphorylation in proteostasis and the heat shock response. The research will be conducted by the University of North Carolina at Charlotte and will examine how phosphorylation of the Hsp70 molecular chaperone impacts its function in yeast, particularly related to the...