Project Grant R35GM158251
- This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental scientific research to study the mechanisms of how homologous recombination maintains genomic stability and induces genome rearrangements. The $305,927 award, effective September 1, 2025, will enable researchers at the University of California, Davis to advance their work on understanding the processing of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $445,000 project grant to the Dana-Farber Cancer Institute, Inc. (DFCI) in Boston, Massachusetts. The grant, awarded on January 22, 2025, supports DFCI's research on the molecular mechanisms of DNA double-strand break repair by homologous recombination, a critical process for cell survival and cancer prevention. The project aims to define the complex...
- This Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $495,594.00 to the University of California, Santa Barbara to conduct research on the mechanisms underlying DNA double-strand break repair through homologous recombination. The objectives of this 5-year project are to 1) define the steps in recombination altered by DNA interstrand crosslinks, 2) explore how the DNA repair regulatory kinase ATR is activated during double-strand break...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
- This federal Project Grant award of $617,007 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on the molecular mechanisms of DNA double-strand break repair through non-homologous end joining (NHEJ). The research aims to elucidate how DNA ends are held together and coordinated with end processing enzymes to maximize the fidelity of NHEJ and minimize genome alterations. The...
- This federal Project Grant award of $1,943,750.00, awarded on August 8, 2025, is provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research and advanced training focused on understanding the molecular mechanisms that regulate the mitotic DNA damage response. The project, led by researchers at The Washington University, aims to 1) reveal how ubiquitinated histone H2A acts...
- This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair during meiosis, leading to the formation of de novo structural variants. The $380,495 award, with a project period from February 1, 2025 to January 31, 2030, will be performed by the Regents of the University of Michigan. The...
- This $289,856 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to elucidate the molecular and structural mechanisms underlying the licensing of DNA replication origins in multicellular eukaryotes. The research will employ biochemical, biophysical, and structural biology approaches to resolve how metazoan MCM helicase loading intermediates mature into active replication...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000.00 to The Regents of the University of Colorado (University of Colorado-Denver) to conduct research on the molecular mechanisms of DNA replication during mitosis. The research aims to uncover how cells complete replication of the entire genome before cell division, even when replication is not fully finished in the S phase of...
- This Project Grant award under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences (NIGMS), supports research on the mechanisms of protein sumoylation and its role in DNA repair. The $148,228 award to Texas State University will be used to determine how DNA binding, ATP hydrolysis, and sumo interactions of the subunits of the SMC5/6 complex contribute to the efficient sumoylation of key proteins involved in...
This $516,608 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the mechanisms and regulation of DNA recombination in budding and fission yeast. The key research focus areas are: 1) studying DNA end resection, the critical first step in homologous recombination, within heterochromatin regions, 2) investigating how lagging strand synthesis proceeds during break-induced replication and what mechanisms restrict it to subtelomeric regions, and 3) examining additional aspects of DNA double-strand break repair pathways. This foundational research aims to elucidate the fundamental biological processes underlying DNA repair and maintenance of genomic stability, which is essential for preventing diseases like cancer and immune deficiencies. The award has a period of performance from August 1, 2025 to July 31, 2030 and is being conducted by Baylor College of Medicine, a prestigious private non-profit research university in Texas.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $516.6k | 7/25/25 |